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• W2750463384 abstract "Significance Ewing sarcoma is a pediatric bone malignancy driven by the fusion protein EWS/FLI. EWS/FLI mediates oncogenesis through its role as an aberrant transcription factor, but little is known about molecular mechanisms underlying this function. We demonstrate in Ewing sarcoma cells that EWS/FLI activates gene targets through binding at associated GGAA-microsatellites, and these repetitive sequences are necessary for Ewing sarcoma cell proliferation and anchorage-independent growth. Furthermore, we show a previously unknown role for the EWS portion of the fusion protein as critical in binding at EWS/FLI targets. Understanding the mechanism of EWS/FLI transcriptional regulation is imperative to expose novel, targetable biology to inhibit its function. Additionally, these insights provide a useful model for understanding the molecular complexities of other pediatric cancers." @default.
• W2750463384 created "2017-08-31" @default.
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• W2750463384 date "2017-08-28" @default.
• W2750463384 modified "2023-10-16" @default.
• W2750463384 title "Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth" @default.
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• W2750463384 doi "https://doi.org/10.1073/pnas.1701872114" @default.
• W2750463384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5603999" @default.
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• W2750463384 hasPublicationYear "2017" @default.
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