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- W2750512323 abstract "The aim of the present study was to investigate polymorphisms and haplotypes of MICA, D6S2927 and D6S2793 microsatellites and linkage disequlibria (D) between these microsatellite loci and HLA-B in the Croatian population. A total of 179 healthy unrelated Croatians were studied using PCR amplification and electrophoresis on 6% polyacrylamide gel in an automated sequencer (ALFexpress). In total, 6 alleles of D6S2927, 5 alleles of MICA microsatellite locus and 14 alleles of D6S2793 microsatellites were observed. At D6S2927 locus most common allele was D6S2927-4 (23.5%), MICA-5.1 allele was the most frequent (27.6%) at MICA microsatellite, while at D6S2793 locus the most frequent was D6S2793-CA15 (13.1%). Eight HLA-B/D6S2927 haplotypic associations (B*07/D6S2927-4, B*08/D6S2927-3, B*18/D6S2927-3, B*27/D6S2927-1, B*35/D6S2927-5, B*38/D6S2927-4, B*51/D6S2927-32 and B*61/D6S2927-1) showed strong association (p 0.5). Among 88 different HLA-B/MICA haplotypic associations, seven combinations (B*07/MICA-5.1, B*08/MICA-5.1, B*15/MICA-5, B*18/MICA-4, B*27/MICA-4, B*38/MICA-9 and B*51/MICA-6) demonstrated high linkage (D>0.5) with significant p value (p 0.5, p<0.001) for the following combinations: D6S2927-5/MICA-9, D6S2927-3/D6S2793-CA25, D6S2927-4/D6S2793-CA17, D6S2927-3/D6S273-4, D6S2927-3/D6S273-7 and D6S2793-CA26/D6S273-4. These results provide data about region around HLA-B locus which is very attractive because of its contribution to genetic susceptibility for many HLA associated disease and will help in all further HLA-B locus associated disease studies." @default.
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- W2750512323 date "2006-06-11" @default.
- W2750512323 modified "2023-09-26" @default.
- W2750512323 title "Study of microsatellite polymorphisms around HLA-B locus in the Croatian population" @default.
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