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• W2750572010 abstract "Aims . Obesity is accompanied by the formation of oxygen free radicals, whose intensified activity without effective defense mechanisms can lead to oxidative stress and related complications. We evaluated the presence of oxidative stress in obese prepubertal children. Methods . The study included 83 healthy children aged 2–10 years (62 with obesity and 21 nonobese controls). Total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidized low-density lipoprotein (ox-LDL), lipid parameters, glucose, and C-reactive protein (CRP) were measured in serum. Oxidative stress index (OSI) was calculated. Results . Serum TOC concentration was significantly higher (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>) and TAC concentration was lower (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>) in obese children. OSI was higher (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.01</mml:mn></mml:math>) in obese subjects compared with controls. CRP levels were normal in all children, but median CRP value was higher (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.01</mml:mn></mml:math>) and HDL cholesterol levels were lower (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>) in the obese group. We found a significant negative correlation between TAC and ox-LDL concentrations (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mo>−</mml:mo><mml:mn>0.27</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>) in obese children. Furthermore, obesity duration was positively correlated with TOC level (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.32</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>) in this group. Conclusions . Obesity-related oxidative stress already occurs in prepubescence. Early obesity diagnosis and the necessary therapeutic activity implementation is a vital strategy for the prophylaxis of free radical damage and related multiorgan complications." @default.
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• W2750572010 date "2017-01-01" @default.
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• W2750572010 title "Total Oxidant and Antioxidant Status in Prepubertal Children with Obesity" @default.
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• W2750572010 doi "https://doi.org/10.1155/2017/5621989" @default.
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