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- W2750623698 abstract "An expedient synthesis of coumarin-pyridone conjugate molecules 2a-o is reported via one-pot reaction between (E)-3-(3-arylacryloyl)-2H-chromen-2-ones 1a-o, ethyl 2-nitroacetate and ammonium acetate. The structures of synthesized compounds have been unambiguously confirmed by spectroscopic analyses (NMR, IR and MS). All the compounds were screened for their anti-microbial activities against three Gram-positive bacterial strains, two Gram-negative bacterial strains and four fungal organisms. Compounds 2d, 2i, 2k, 2o exhibited mild anti-bacterial activity and 2d, 2m were found to be moderately active against all the tested fungal organisms. Compound 2k showed good inhibitory potential against the tested yeasts organisms. Expedient synthesis of coumarin-pyridone conjugate molecules has been reported via one-pot, three-component reaction between (E)-3-(3-arylacryloyl)-2H-chromen-2-ones, ethyl 2-nitroacetate and ammonium acetate. Anti-microbial activity of these compounds was evaluated and the results indicated that some of the compounds exhibited mild anti-bacterial activity and good inhibitory potential against the tested fungal organisms." @default.
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- W2750623698 date "2017-09-06" @default.
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- W2750623698 title "Expeditious synthesis of coumarin-pyridone conjugates molecules and their anti-microbial evaluation" @default.
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- W2750623698 doi "https://doi.org/10.1007/s12039-017-1362-7" @default.
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