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• W2750652822 abstract "Skeletal muscle metabolic and contractile properties are reliant on muscle mitochondrial and myofibrillar protein turnover. The turnover of these specific protein pools is compromised during disease, ageing, and inactivity. Oppositely, exercise can accentuate muscle protein turnover, thereby counteracting decay in muscle function. According to a traditional consensus, endurance exercise is required to drive mitochondrial adaptations, while resistance exercise is required to drive myofibrillar adaptations. However, concurrent practice of traditional endurance exercise and resistance exercise regimens to achieve both types of muscle adaptations is time-consuming, motivationally demanding, and contended to entail practice at intensity levels, that may not comply with clinical settings. It is therefore of principle interest to identify effective, yet feasible, exercise strategies that may positively affect both mitochondrial and myofibrillar protein turnover. Recently, reports indicate that traditional high-load resistance exercise can stimulate muscle mitochondrial biogenesis and mitochondrial respiratory function. Moreover, fatiguing low-load resistance exercise has been shown capable of promoting muscle hypertrophy and expectedly entails greater metabolic stress to potentially enhance mitochondrial adaptations. Consequently, fatiguing low-load resistance exercise regimens may possess the ability to stimulate muscle mitochondrial adaptations without compromising muscle myofibrillar accretion. However, the exact ability of resistance exercise to drive mitochondrial adaptations is debatable, not least due to some methodological challenges. The current review therefore aims to address the evidence on the effects of resistance exercise on skeletal muscle mitochondrial biogenesis, content and function. In prolongation, a perspective is taken on the specific potential of low-load resistance exercise on promoting mitochondrial adaptations." @default.
• W2750652822 created "2017-09-15" @default.
• W2750652822 creator A5023566295 @default.
• W2750652822 creator A5087716276 @default.
• W2750652822 date "2017-09-15" @default.
• W2750652822 modified "2023-09-30" @default.
• W2750652822 title "Impact of Resistance Training on Skeletal Muscle Mitochondrial Biogenesis, Content, and Function" @default.
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• W2750652822 doi "https://doi.org/10.3389/fphys.2017.00713" @default.
• W2750652822 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5605648" @default.
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• W2750652822 hasPublicationYear "2017" @default.
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