Matches in SemOpenAlex for { <https://semopenalex.org/work/W2750688768> ?p ?o ?g. }
- W2750688768 endingPage "1868" @default.
- W2750688768 startingPage "1868" @default.
- W2750688768 abstract "In recent years, the relevance of the immune system to fight cancer has led to the development of immunotherapy, including the adoptive cell transfer of immune cells, such as natural killer (NK) cells and chimeric antigen receptors (CAR)-modified T cells. The discovery of donor NK cells’ anti-tumor activity in acute myeloid leukemia patients receiving allogeneic stem cell transplantation (allo-SCT) was the trigger to conduct many clinical trials infusing NK cells. Surprisingly, many of these studies did not obtain optimal results, suggesting that many different NK cell parameters combined with the best clinical protocol need to be optimized. Various parameters including the high array of activating receptors that NK cells have, the source of NK cells selected to treat patients, different cytotoxic mechanisms that NK cells activate depending on the target cell and tumor cell survival mechanisms need to be considered before choosing the best immunotherapeutic strategy using NK cells. In this review, we will discuss these parameters to help improve current strategies using NK cells in cancer therapy. Moreover, the chimeric antigen receptor (CAR) modification, which has revolutionized the concept of immunotherapy, will be discussed in the context of NK cells. Lastly, the dark side of NK cells and their involvement in inflammation will also be discussed." @default.
- W2750688768 created "2017-09-15" @default.
- W2750688768 creator A5012535366 @default.
- W2750688768 creator A5017951406 @default.
- W2750688768 creator A5028969206 @default.
- W2750688768 creator A5068807291 @default.
- W2750688768 creator A5079200899 @default.
- W2750688768 date "2017-08-29" @default.
- W2750688768 modified "2023-10-18" @default.
- W2750688768 title "Natural Killer Cells: Angels and Devils for Immunotherapy" @default.
- W2750688768 cites W1134938859 @default.
- W2750688768 cites W146746805 @default.
- W2750688768 cites W1508892593 @default.
- W2750688768 cites W1528349069 @default.
- W2750688768 cites W1537599002 @default.
- W2750688768 cites W1582617014 @default.
- W2750688768 cites W1645098973 @default.
- W2750688768 cites W1845250843 @default.
- W2750688768 cites W1864919249 @default.
- W2750688768 cites W1951555862 @default.
- W2750688768 cites W1967920980 @default.
- W2750688768 cites W1969950463 @default.
- W2750688768 cites W1969961365 @default.
- W2750688768 cites W1981137720 @default.
- W2750688768 cites W1984252017 @default.
- W2750688768 cites W1989712520 @default.
- W2750688768 cites W1995275059 @default.
- W2750688768 cites W1997666580 @default.
- W2750688768 cites W1998007325 @default.
- W2750688768 cites W1999080932 @default.
- W2750688768 cites W2007108179 @default.
- W2750688768 cites W2007333986 @default.
- W2750688768 cites W2008182044 @default.
- W2750688768 cites W2011562061 @default.
- W2750688768 cites W2013716230 @default.
- W2750688768 cites W2015054607 @default.
- W2750688768 cites W2016523043 @default.
- W2750688768 cites W2017584680 @default.
- W2750688768 cites W2017936152 @default.
- W2750688768 cites W2018922991 @default.
- W2750688768 cites W2022580424 @default.
- W2750688768 cites W2027053879 @default.
- W2750688768 cites W2034071655 @default.
- W2750688768 cites W2039001050 @default.
- W2750688768 cites W2044502434 @default.
- W2750688768 cites W2046237540 @default.
- W2750688768 cites W2051890542 @default.
- W2750688768 cites W2054499416 @default.
- W2750688768 cites W2056315817 @default.
- W2750688768 cites W2059142229 @default.
- W2750688768 cites W2059738518 @default.
- W2750688768 cites W2066082105 @default.
- W2750688768 cites W2074007150 @default.
- W2750688768 cites W2075049419 @default.
- W2750688768 cites W2076352025 @default.
- W2750688768 cites W2078422320 @default.
- W2750688768 cites W2079870561 @default.
- W2750688768 cites W2081053802 @default.
- W2750688768 cites W2081848012 @default.
- W2750688768 cites W2086952774 @default.
- W2750688768 cites W2087441379 @default.
- W2750688768 cites W2090858884 @default.
- W2750688768 cites W2090895423 @default.
- W2750688768 cites W2091675007 @default.
- W2750688768 cites W2092215629 @default.
- W2750688768 cites W2092303252 @default.
- W2750688768 cites W2099910228 @default.
- W2750688768 cites W2101684276 @default.
- W2750688768 cites W2103617635 @default.
- W2750688768 cites W2105400883 @default.
- W2750688768 cites W2105557870 @default.
- W2750688768 cites W2118796952 @default.
- W2750688768 cites W2121374455 @default.
- W2750688768 cites W2122684432 @default.
- W2750688768 cites W2132835748 @default.
- W2750688768 cites W2132954482 @default.
- W2750688768 cites W2134582553 @default.
- W2750688768 cites W2145055473 @default.
- W2750688768 cites W2145786937 @default.
- W2750688768 cites W2146494327 @default.
- W2750688768 cites W2147068163 @default.
- W2750688768 cites W2153548762 @default.
- W2750688768 cites W2157553399 @default.
- W2750688768 cites W2162377851 @default.
- W2750688768 cites W2165635676 @default.
- W2750688768 cites W2169289106 @default.
- W2750688768 cites W2171295459 @default.
- W2750688768 cites W2192976324 @default.
- W2750688768 cites W2253944138 @default.
- W2750688768 cites W2258216786 @default.
- W2750688768 cites W2260497117 @default.
- W2750688768 cites W2260702256 @default.
- W2750688768 cites W2283739034 @default.
- W2750688768 cites W2287084147 @default.
- W2750688768 cites W2297284707 @default.
- W2750688768 cites W2331460180 @default.
- W2750688768 cites W2338392504 @default.
- W2750688768 cites W2402659606 @default.