Matches in SemOpenAlex for { <https://semopenalex.org/work/W2750764319> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2750764319 endingPage "131" @default.
- W2750764319 startingPage "130" @default.
- W2750764319 abstract "CR3 and CR4 belong to the family of β2-integrins and play an important role in phagocytosis, cellular adherence and migration. CR3 and CR4 are generally expected to mediate similar functions due to their structural homology, overlapping ligand specificity and parallel expression on human phagocytes. Although the different signalling pathways of these receptors suggest distinct functions, possible differences are just being revealed.Previously we proved that CR3 plays a key role in the uptake of iC3b-opsonized particles by human dendritic cells. Now, besides measuring the overall phagocytic capacity of cells including the assessment of surface bound as well as internalized particles, we extended our investigations and studied the digestion of the iC3b opsonized antigen by various human phagocytes. The participation of CR3 and CR4 was compared in the process of binding, internalization and digestion of iC3b opsonized Staphylococcus aureus by monocytes, monocyte derived macrophages (MDMs), monocyte derived dendritic cells (MDDCs), and neutrophils. Comparing the activity of the two β2-integrin type complement receptors we found that CR3 plays a dominant role in the phagocytosis of iC3b opsonized S. aureus by all of these cell types.Studying another important integrin-mediated function we demonstrated earlier that CR4 is dominant in the adhesion of monocytes, MDMs and MDDCs to fibrinogen. Here we studied the participation of CR3 and CR4 in podosome formation by human phagocytes, since these structures are known to play an essential role in cell migration. Our confocal microscopy analysis revealed that both CD11b and CD11c concentrate in the podosome adhesion ring.In summary our data highlight differences in the function of human CR3 and CR4 in the process of uptake and digestion of complement opsonized antigen, while in the process of podosome formation, connected to cellular motility, both receptors equally take part." @default.
- W2750764319 created "2017-09-15" @default.
- W2750764319 creator A5006549290 @default.
- W2750764319 creator A5007450217 @default.
- W2750764319 creator A5015870327 @default.
- W2750764319 creator A5031299889 @default.
- W2750764319 creator A5036984757 @default.
- W2750764319 creator A5039114113 @default.
- W2750764319 creator A5056055710 @default.
- W2750764319 creator A5063144693 @default.
- W2750764319 creator A5067018409 @default.
- W2750764319 creator A5068553618 @default.
- W2750764319 creator A5088670019 @default.
- W2750764319 date "2017-09-01" @default.
- W2750764319 modified "2023-09-24" @default.
- W2750764319 title "Interaction of complement defence collagens C1q and MBL with BMP-1/tolloid-like proteinases" @default.
- W2750764319 doi "https://doi.org/10.1016/j.molimm.2017.06.063" @default.
- W2750764319 hasPublicationYear "2017" @default.
- W2750764319 type Work @default.
- W2750764319 sameAs 2750764319 @default.
- W2750764319 citedByCount "0" @default.
- W2750764319 crossrefType "journal-article" @default.
- W2750764319 hasAuthorship W2750764319A5006549290 @default.
- W2750764319 hasAuthorship W2750764319A5007450217 @default.
- W2750764319 hasAuthorship W2750764319A5015870327 @default.
- W2750764319 hasAuthorship W2750764319A5031299889 @default.
- W2750764319 hasAuthorship W2750764319A5036984757 @default.
- W2750764319 hasAuthorship W2750764319A5039114113 @default.
- W2750764319 hasAuthorship W2750764319A5056055710 @default.
- W2750764319 hasAuthorship W2750764319A5063144693 @default.
- W2750764319 hasAuthorship W2750764319A5067018409 @default.
- W2750764319 hasAuthorship W2750764319A5068553618 @default.
- W2750764319 hasAuthorship W2750764319A5088670019 @default.
- W2750764319 hasConcept C104317684 @default.
- W2750764319 hasConcept C111684460 @default.
- W2750764319 hasConcept C127716648 @default.
- W2750764319 hasConcept C139770010 @default.
- W2750764319 hasConcept C141073059 @default.
- W2750764319 hasConcept C142669718 @default.
- W2750764319 hasConcept C1491633281 @default.
- W2750764319 hasConcept C160448771 @default.
- W2750764319 hasConcept C170493617 @default.
- W2750764319 hasConcept C171779818 @default.
- W2750764319 hasConcept C175773311 @default.
- W2750764319 hasConcept C185592680 @default.
- W2750764319 hasConcept C191590540 @default.
- W2750764319 hasConcept C195687474 @default.
- W2750764319 hasConcept C203014093 @default.
- W2750764319 hasConcept C2779919695 @default.
- W2750764319 hasConcept C55493867 @default.
- W2750764319 hasConcept C85789140 @default.
- W2750764319 hasConcept C86803240 @default.
- W2750764319 hasConcept C8891405 @default.
- W2750764319 hasConcept C89372155 @default.
- W2750764319 hasConcept C95444343 @default.
- W2750764319 hasConceptScore W2750764319C104317684 @default.
- W2750764319 hasConceptScore W2750764319C111684460 @default.
- W2750764319 hasConceptScore W2750764319C127716648 @default.
- W2750764319 hasConceptScore W2750764319C139770010 @default.
- W2750764319 hasConceptScore W2750764319C141073059 @default.
- W2750764319 hasConceptScore W2750764319C142669718 @default.
- W2750764319 hasConceptScore W2750764319C1491633281 @default.
- W2750764319 hasConceptScore W2750764319C160448771 @default.
- W2750764319 hasConceptScore W2750764319C170493617 @default.
- W2750764319 hasConceptScore W2750764319C171779818 @default.
- W2750764319 hasConceptScore W2750764319C175773311 @default.
- W2750764319 hasConceptScore W2750764319C185592680 @default.
- W2750764319 hasConceptScore W2750764319C191590540 @default.
- W2750764319 hasConceptScore W2750764319C195687474 @default.
- W2750764319 hasConceptScore W2750764319C203014093 @default.
- W2750764319 hasConceptScore W2750764319C2779919695 @default.
- W2750764319 hasConceptScore W2750764319C55493867 @default.
- W2750764319 hasConceptScore W2750764319C85789140 @default.
- W2750764319 hasConceptScore W2750764319C86803240 @default.
- W2750764319 hasConceptScore W2750764319C8891405 @default.
- W2750764319 hasConceptScore W2750764319C89372155 @default.
- W2750764319 hasConceptScore W2750764319C95444343 @default.
- W2750764319 hasLocation W27507643191 @default.
- W2750764319 hasOpenAccess W2750764319 @default.
- W2750764319 hasPrimaryLocation W27507643191 @default.
- W2750764319 hasRelatedWork W2100525242 @default.
- W2750764319 hasRelatedWork W2347184676 @default.
- W2750764319 hasRelatedWork W2619613072 @default.
- W2750764319 hasRelatedWork W2753628059 @default.
- W2750764319 hasRelatedWork W2753635465 @default.
- W2750764319 hasRelatedWork W2753826191 @default.
- W2750764319 hasRelatedWork W4229941015 @default.
- W2750764319 hasRelatedWork W4231422892 @default.
- W2750764319 hasRelatedWork W4294276610 @default.
- W2750764319 hasRelatedWork W4323349841 @default.
- W2750764319 hasVolume "89" @default.
- W2750764319 isParatext "false" @default.
- W2750764319 isRetracted "false" @default.
- W2750764319 magId "2750764319" @default.
- W2750764319 workType "article" @default.