Matches in SemOpenAlex for { <https://semopenalex.org/work/W2750871530> ?p ?o ?g. }
- W2750871530 endingPage "2679" @default.
- W2750871530 startingPage "2652" @default.
- W2750871530 abstract "Chronic pain constitutes a significant and expanding worldwide health crisis. Currently available analgesics poorly serve individuals suffering from chronic pain, and new therapeutic agents that are more effective, safer, and devoid of abuse liabilities are desperately needed. Among the myriad of cellular and molecular processes contributing to chronic pain, spinal disinhibition of pain signaling to higher cortical centers plays a critical role. Accumulating evidence shows that glycinergic inhibitory neurotransmission in the spinal cord dorsal horn gates nociceptive signaling, is essential in maintaining physiological pain sensitivity, and is diminished in pathological pain states. Thus, it is hypothesized that agents capable of enhancing glycinergic tone within the dorsal horn could obtund nociceptor signaling to the brain and serve as analgesics for persistent pain. This Perspective highlights the potential that pharmacotherapies capable of increasing inhibitory spinal glycinergic neurotransmission hold in providing new and transformative analgesic therapies for the treatment of chronic pain." @default.
- W2750871530 created "2017-09-15" @default.
- W2750871530 creator A5004832791 @default.
- W2750871530 date "2017-09-06" @default.
- W2750871530 modified "2023-10-13" @default.
- W2750871530 title "Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain" @default.
- W2750871530 cites W1482769507 @default.
- W2750871530 cites W1487689711 @default.
- W2750871530 cites W1496464433 @default.
- W2750871530 cites W1520866342 @default.
- W2750871530 cites W1548920698 @default.
- W2750871530 cites W1549810436 @default.
- W2750871530 cites W1552169386 @default.
- W2750871530 cites W1552918907 @default.
- W2750871530 cites W1560013893 @default.
- W2750871530 cites W1560430068 @default.
- W2750871530 cites W1561436076 @default.
- W2750871530 cites W1583295078 @default.
- W2750871530 cites W1607638275 @default.
- W2750871530 cites W1668093331 @default.
- W2750871530 cites W1785667419 @default.
- W2750871530 cites W1845055155 @default.
- W2750871530 cites W1852646540 @default.
- W2750871530 cites W1901708675 @default.
- W2750871530 cites W1902775329 @default.
- W2750871530 cites W1905325352 @default.
- W2750871530 cites W1963740158 @default.
- W2750871530 cites W1964949657 @default.
- W2750871530 cites W1965999023 @default.
- W2750871530 cites W1966203252 @default.
- W2750871530 cites W1967776969 @default.
- W2750871530 cites W1968490089 @default.
- W2750871530 cites W1969131602 @default.
- W2750871530 cites W1969167720 @default.
- W2750871530 cites W1969252912 @default.
- W2750871530 cites W1969274892 @default.
- W2750871530 cites W1970096466 @default.
- W2750871530 cites W1971066754 @default.
- W2750871530 cites W1973081932 @default.
- W2750871530 cites W1976598489 @default.
- W2750871530 cites W1976926408 @default.
- W2750871530 cites W1977645063 @default.
- W2750871530 cites W1977700300 @default.
- W2750871530 cites W1978269241 @default.
- W2750871530 cites W1979382407 @default.
- W2750871530 cites W1979655595 @default.
- W2750871530 cites W1979675387 @default.
- W2750871530 cites W1980983414 @default.
- W2750871530 cites W1981238903 @default.
- W2750871530 cites W1982009183 @default.
- W2750871530 cites W1984010212 @default.
- W2750871530 cites W1984832858 @default.
- W2750871530 cites W1985267805 @default.
- W2750871530 cites W1985326569 @default.
- W2750871530 cites W1985500649 @default.
- W2750871530 cites W1985880659 @default.
- W2750871530 cites W1986063515 @default.
- W2750871530 cites W1987816196 @default.
- W2750871530 cites W1988059170 @default.
- W2750871530 cites W1990682957 @default.
- W2750871530 cites W1990816409 @default.
- W2750871530 cites W1990912842 @default.
- W2750871530 cites W1991098584 @default.
- W2750871530 cites W1991183604 @default.
- W2750871530 cites W1991248843 @default.
- W2750871530 cites W1991555777 @default.
- W2750871530 cites W1991972341 @default.
- W2750871530 cites W1992680999 @default.
- W2750871530 cites W1993828485 @default.
- W2750871530 cites W1996536705 @default.
- W2750871530 cites W1999061814 @default.
- W2750871530 cites W1999283911 @default.
- W2750871530 cites W2000214690 @default.
- W2750871530 cites W2001814576 @default.
- W2750871530 cites W2002367189 @default.
- W2750871530 cites W2003872067 @default.
- W2750871530 cites W2004910630 @default.
- W2750871530 cites W2005396232 @default.
- W2750871530 cites W2005829345 @default.
- W2750871530 cites W2007936528 @default.
- W2750871530 cites W2008243901 @default.
- W2750871530 cites W2008472628 @default.
- W2750871530 cites W2008543586 @default.
- W2750871530 cites W2009399717 @default.
- W2750871530 cites W2009473514 @default.
- W2750871530 cites W2009925245 @default.
- W2750871530 cites W2010841889 @default.
- W2750871530 cites W2011831455 @default.
- W2750871530 cites W2012459235 @default.
- W2750871530 cites W2012590118 @default.
- W2750871530 cites W2014779151 @default.
- W2750871530 cites W2015386261 @default.
- W2750871530 cites W2016474170 @default.
- W2750871530 cites W2018579572 @default.
- W2750871530 cites W2019974245 @default.
- W2750871530 cites W2021375500 @default.
- W2750871530 cites W2021842829 @default.
- W2750871530 cites W2023961778 @default.