FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2750891727> ?p ?o ?g. }

• W2750891727 endingPage "84" @default.
• W2750891727 startingPage "77" @default.
• W2750891727 abstract "We previously reported that systemic administration of the selective delta opioid receptor (DOP) agonist KNT-127 produces potent anxiolytic-like effects in rats. Although a higher distribution pattern of DOPs was reported in the prelimbic medial prefrontal cortex (PL-PFC) of rodents, the role of DOPs in PL-PFC and in anxiolytic-like effects have not been well examined. Recently, we demonstrated that activation of PL-PFC with the sodium channel activator veratrine increases glutamatergic neurotransmission and produces anxiety-like behaviors in mice. Therefore, we investigated the effects of co-perfusion with KNT-127 in PL-PFC on veratrine-induced anxiety-like behaviors in mice. We also simultaneously measured extracellular glutamate and GABA levels. In addition, we assessed the effect of KNT-127 on the expression of c-Fos in sub-regions of the amygdala. Extracellular glutamate levels were measured in seven-week-old male C57BL/6N mice using an in vivo microdialysis-HPLC/ECD system, and behaviors were assessed simultaneously in an open field test. Basal levels of glutamate were measured by collecting samples every 10min for 60min. The drug-containing medium was perfused for 30min, and the open field test was performed during the last 10min of drug perfusion. After drug treatments, the perfusion was switched from drug-containing medium to control medium without drugs and samples were collected for another 90min. KNT-127 co-perfusion completely diminished veratrine-induced anxiety-like behaviors and attenuated the veratrine-induced increase in extracellular glutamate levels in PL-PFC. Interestingly, KNT-127 perfusion alone in PL-PFC did not affect anxiety-like behaviors. Local perfusion of veratrine in PL-PFC induced c-Fos immunoreactivity in sub-regions of amygdala. Co-perfusion of KNT-127 diminished c-Fos expression. Here we demonstrate that the DOP agonist KNT-127 in PL-PFC attenuates veratrine-induced anxiety-like behaviors in mice. These effects may be caused by the presynaptic suppression of activated glutamatergic transmission in PL-PFC, which projects to sub-regions of the amygdala. We propose that compounds like KNT-127, which inhibit glutamatergic transmission in PL-PFC, are candidates for novel anxiolytics." @default.
• W2750891727 created "2017-09-15" @default.
• W2750891727 creator A5000167582 @default.
• W2750891727 creator A5029754237 @default.
• W2750891727 creator A5036803703 @default.
• W2750891727 creator A5059327923 @default.
• W2750891727 creator A5060895352 @default.
• W2750891727 creator A5068736197 @default.
• W2750891727 creator A5080120159 @default.
• W2750891727 creator A5081961241 @default.
• W2750891727 date "2018-01-01" @default.
• W2750891727 modified "2023-09-25" @default.
• W2750891727 title "The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice" @default.
• W2750891727 cites W1965792012 @default.
• W2750891727 cites W1979929704 @default.
• W2750891727 cites W1989982790 @default.
• W2750891727 cites W1990753952 @default.
• W2750891727 cites W1998165867 @default.
• W2750891727 cites W2002531126 @default.
• W2750891727 cites W2008182839 @default.
• W2750891727 cites W2015184509 @default.
• W2750891727 cites W2029707041 @default.
• W2750891727 cites W2036214063 @default.
• W2750891727 cites W2054315926 @default.
• W2750891727 cites W2057627385 @default.
• W2750891727 cites W2060978874 @default.
• W2750891727 cites W2074061123 @default.
• W2750891727 cites W2083136363 @default.
• W2750891727 cites W2083844864 @default.
• W2750891727 cites W2095108407 @default.
• W2750891727 cites W2114770633 @default.
• W2750891727 cites W2119106093 @default.
• W2750891727 cites W2140257707 @default.
• W2750891727 cites W2279203193 @default.
• W2750891727 doi "https://doi.org/10.1016/j.bbr.2017.08.041" @default.
• W2750891727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28864205" @default.
• W2750891727 hasPublicationYear "2018" @default.
• W2750891727 type Work @default.
• W2750891727 sameAs 2750891727 @default.
• W2750891727 citedByCount "16" @default.
• W2750891727 countsByYear W27508917272018 @default.
• W2750891727 countsByYear W27508917272019 @default.
• W2750891727 countsByYear W27508917272020 @default.
• W2750891727 countsByYear W27508917272021 @default.
• W2750891727 countsByYear W27508917272022 @default.
• W2750891727 countsByYear W27508917272023 @default.
• W2750891727 crossrefType "journal-article" @default.
• W2750891727 hasAuthorship W2750891727A5000167582 @default.
• W2750891727 hasAuthorship W2750891727A5029754237 @default.
• W2750891727 hasAuthorship W2750891727A5036803703 @default.
• W2750891727 hasAuthorship W2750891727A5059327923 @default.
• W2750891727 hasAuthorship W2750891727A5060895352 @default.
• W2750891727 hasAuthorship W2750891727A5068736197 @default.
• W2750891727 hasAuthorship W2750891727A5080120159 @default.
• W2750891727 hasAuthorship W2750891727A5081961241 @default.
• W2750891727 hasConcept C126322002 @default.
• W2750891727 hasConcept C134018914 @default.
• W2750891727 hasConcept C15744967 @default.
• W2750891727 hasConcept C169760540 @default.
• W2750891727 hasConcept C169900460 @default.
• W2750891727 hasConcept C170493617 @default.
• W2750891727 hasConcept C185592680 @default.
• W2750891727 hasConcept C2777765862 @default.
• W2750891727 hasConcept C2778938600 @default.
• W2750891727 hasConcept C2780451725 @default.
• W2750891727 hasConcept C2780648746 @default.
• W2750891727 hasConcept C2781063702 @default.
• W2750891727 hasConcept C2781195155 @default.
• W2750891727 hasConcept C28406088 @default.
• W2750891727 hasConcept C50156730 @default.
• W2750891727 hasConcept C55493867 @default.
• W2750891727 hasConcept C61174792 @default.
• W2750891727 hasConcept C71924100 @default.
• W2750891727 hasConcept C98274493 @default.
• W2750891727 hasConceptScore W2750891727C126322002 @default.
• W2750891727 hasConceptScore W2750891727C134018914 @default.
• W2750891727 hasConceptScore W2750891727C15744967 @default.
• W2750891727 hasConceptScore W2750891727C169760540 @default.
• W2750891727 hasConceptScore W2750891727C169900460 @default.
• W2750891727 hasConceptScore W2750891727C170493617 @default.
• W2750891727 hasConceptScore W2750891727C185592680 @default.
• W2750891727 hasConceptScore W2750891727C2777765862 @default.
• W2750891727 hasConceptScore W2750891727C2778938600 @default.
• W2750891727 hasConceptScore W2750891727C2780451725 @default.
• W2750891727 hasConceptScore W2750891727C2780648746 @default.
• W2750891727 hasConceptScore W2750891727C2781063702 @default.
• W2750891727 hasConceptScore W2750891727C2781195155 @default.
• W2750891727 hasConceptScore W2750891727C28406088 @default.
• W2750891727 hasConceptScore W2750891727C50156730 @default.
• W2750891727 hasConceptScore W2750891727C55493867 @default.
• W2750891727 hasConceptScore W2750891727C61174792 @default.
• W2750891727 hasConceptScore W2750891727C71924100 @default.
• W2750891727 hasConceptScore W2750891727C98274493 @default.
• W2750891727 hasLocation W27508917271 @default.
• W2750891727 hasLocation W27508917272 @default.
• W2750891727 hasOpenAccess W2750891727 @default.
• W2750891727 hasPrimaryLocation W27508917271 @default.
• W2750891727 hasRelatedWork W1736866876 @default.

• next