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- W2750936476 abstract "Adhesins are crucial virulence factors of pathogenic bacteria involved in colonization, transmission and pathogenesis. Many bacterial genomes contain the information for a surprisingly large number of diverse adhesive structures. One prominent example is the invasive and facultative intracellular pathogen Salmonella enterica with an adhesiome of up to 20 adhesins. Such large repertoire of adhesins contributes to colonization of a broad range of host species and may allow adaptation to various environments within the host, as well as in non-host environments. For S. enterica, only few members of the adhesiome are functionally expressed under laboratory conditions, and accordingly the structural and functional understanding of the majority of adhesins is sparse. We have devised a simple and versatile approach to functionally express all adhesins of S. enterica serotype Typhimurium, either within Salmonella or within heterologous hosts such as Escherichia coli. We demonstrate the surface expression of various so far cryptic adhesins and show ultrastructural features using atomic force microscopy and transmission electron microscopy. In summary, we report for the first time the expression of the entire adhesiome of S. enterica serotype Typhimurium." @default.
- W2750936476 created "2017-09-15" @default.
- W2750936476 creator A5045865939 @default.
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- W2750936476 creator A5069362573 @default.
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- W2750936476 date "2017-09-04" @default.
- W2750936476 modified "2023-10-17" @default.
- W2750936476 title "Functional expression of the entire adhesiome of Salmonella enterica serotype Typhimurium" @default.
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- W2750936476 doi "https://doi.org/10.1038/s41598-017-10598-2" @default.
- W2750936476 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5583245" @default.
- W2750936476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28871183" @default.
- W2750936476 hasPublicationYear "2017" @default.
- W2750936476 type Work @default.