Matches in SemOpenAlex for { <https://semopenalex.org/work/W2751029436> ?p ?o ?g. }
- W2751029436 abstract "Abstract Predicting the responses of biological systems to ionising radiation is extremely challenging, particularly when comparing X-rays and heavy charged particles, due to the uncertainty in their Relative Biological Effectiveness (RBE). Here we assess the power of a novel mechanistic model of DNA damage repair to predict the sensitivity of cells to X-ray, proton or carbon ion exposures in vitro against over 800 published experiments. By specifying the phenotypic characteristics of cells, the model was able to effectively stratify X-ray radiosensitivity ( R 2 = 0.74) without the use of any cell-specific fitting parameters. This model was extended to charged particle exposures by integrating Monte Carlo calculated dose distributions, and successfully fit to cellular proton radiosensitivity using a single dose-related parameter ( R 2 = 0.66). Using these parameters, the model was also shown to be predictive of carbon ion RBE ( R 2 = 0.77). This model can effectively predict cellular sensitivity to a range of radiations, and has the potential to support developments of personalised radiotherapy independent of radiation type." @default.
- W2751029436 created "2017-09-15" @default.
- W2751029436 creator A5016070046 @default.
- W2751029436 creator A5023199362 @default.
- W2751029436 creator A5037938903 @default.
- W2751029436 creator A5063361338 @default.
- W2751029436 creator A5076875343 @default.
- W2751029436 date "2017-09-07" @default.
- W2751029436 modified "2023-10-01" @default.
- W2751029436 title "A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation" @default.
- W2751029436 cites W1963554507 @default.
- W2751029436 cites W1984266465 @default.
- W2751029436 cites W1986255458 @default.
- W2751029436 cites W1989235871 @default.
- W2751029436 cites W1989340328 @default.
- W2751029436 cites W2005225437 @default.
- W2751029436 cites W2014610710 @default.
- W2751029436 cites W2019219567 @default.
- W2751029436 cites W2021699956 @default.
- W2751029436 cites W2023640892 @default.
- W2751029436 cites W2026812997 @default.
- W2751029436 cites W2056236909 @default.
- W2751029436 cites W2057290654 @default.
- W2751029436 cites W2069628816 @default.
- W2751029436 cites W2071387709 @default.
- W2751029436 cites W2078569105 @default.
- W2751029436 cites W2081566809 @default.
- W2751029436 cites W2081844303 @default.
- W2751029436 cites W2083770395 @default.
- W2751029436 cites W2094202982 @default.
- W2751029436 cites W2096210342 @default.
- W2751029436 cites W2096499183 @default.
- W2751029436 cites W2117181072 @default.
- W2751029436 cites W2119846428 @default.
- W2751029436 cites W2123703108 @default.
- W2751029436 cites W2128158076 @default.
- W2751029436 cites W2133144211 @default.
- W2751029436 cites W2136768706 @default.
- W2751029436 cites W2140186362 @default.
- W2751029436 cites W2159150403 @default.
- W2751029436 cites W2165877571 @default.
- W2751029436 cites W2189227215 @default.
- W2751029436 cites W2198709783 @default.
- W2751029436 cites W2287874371 @default.
- W2751029436 cites W2344855029 @default.
- W2751029436 cites W2465092116 @default.
- W2751029436 cites W2520178269 @default.
- W2751029436 cites W2530793387 @default.
- W2751029436 doi "https://doi.org/10.1038/s41598-017-10820-1" @default.
- W2751029436 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5589818" @default.
- W2751029436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28883414" @default.
- W2751029436 hasPublicationYear "2017" @default.
- W2751029436 type Work @default.
- W2751029436 sameAs 2751029436 @default.
- W2751029436 citedByCount "49" @default.
- W2751029436 countsByYear W27510294362018 @default.
- W2751029436 countsByYear W27510294362019 @default.
- W2751029436 countsByYear W27510294362020 @default.
- W2751029436 countsByYear W27510294362021 @default.
- W2751029436 countsByYear W27510294362022 @default.
- W2751029436 countsByYear W27510294362023 @default.
- W2751029436 crossrefType "journal-article" @default.
- W2751029436 hasAuthorship W2751029436A5016070046 @default.
- W2751029436 hasAuthorship W2751029436A5023199362 @default.
- W2751029436 hasAuthorship W2751029436A5037938903 @default.
- W2751029436 hasAuthorship W2751029436A5063361338 @default.
- W2751029436 hasAuthorship W2751029436A5076875343 @default.
- W2751029436 hasBestOaLocation W27510294361 @default.
- W2751029436 hasConcept C105795698 @default.
- W2751029436 hasConcept C111337013 @default.
- W2751029436 hasConcept C11928243 @default.
- W2751029436 hasConcept C121332964 @default.
- W2751029436 hasConcept C125118446 @default.
- W2751029436 hasConcept C127413603 @default.
- W2751029436 hasConcept C153385146 @default.
- W2751029436 hasConcept C159985019 @default.
- W2751029436 hasConcept C163372243 @default.
- W2751029436 hasConcept C18231593 @default.
- W2751029436 hasConcept C185544564 @default.
- W2751029436 hasConcept C186060115 @default.
- W2751029436 hasConcept C192562407 @default.
- W2751029436 hasConcept C19499675 @default.
- W2751029436 hasConcept C202751555 @default.
- W2751029436 hasConcept C204323151 @default.
- W2751029436 hasConcept C206684579 @default.
- W2751029436 hasConcept C21200559 @default.
- W2751029436 hasConcept C24326235 @default.
- W2751029436 hasConcept C3019137385 @default.
- W2751029436 hasConcept C33923547 @default.
- W2751029436 hasConcept C41008148 @default.
- W2751029436 hasConcept C54355233 @default.
- W2751029436 hasConcept C54516573 @default.
- W2751029436 hasConcept C86611320 @default.
- W2751029436 hasConcept C86803240 @default.
- W2751029436 hasConceptScore W2751029436C105795698 @default.
- W2751029436 hasConceptScore W2751029436C111337013 @default.
- W2751029436 hasConceptScore W2751029436C11928243 @default.
- W2751029436 hasConceptScore W2751029436C121332964 @default.
- W2751029436 hasConceptScore W2751029436C125118446 @default.
- W2751029436 hasConceptScore W2751029436C127413603 @default.