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- W2751055561 endingPage "3431" @default.
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- W2751055561 abstract "Abstract Polyester is commonly used in vascular surgery for patch angioplasty and grafts. We hypothesized that polyester patches heal by infiltration of arterial or venous progenitor cells depending on the site of implantation. Polyester patches were implanted into the Wistar rat aorta or inferior vena cava and explanted on day 7 or 30. Neointima that formed on polyester patches was thicker in the venous environment compared to the amount that formed on patches in the arterial environment. Venous patches had more cell proliferation and greater numbers of VCAM‐positive and CD68‐positive cells, whereas arterial patches had greater numbers of vimentin‐positive and alpha‐actin‐positive cells. Although there were similar numbers of endothelial progenitor cells in the neointimal endothelium, cells in the arterial patch were Ephrin‐B2‐ and notch‐4‐positive while those in the venous patch were Eph‐B4‐ and COUP‐TFII‐positive. Venous patches treated with an arteriovenous fistula had decreased neointimal thickness; neointimal endothelial cells expressed Ephrin‐B2 and notch‐4 in addition to Eph‐B4 and COUP‐TFII. Polyester patches in the venous environment acquire venous identity, whereas patches in the arterial environment acquire arterial identity; patches in the fistula environment acquire dual arterial‐venous identity. These data suggest that synthetic patches heal by acquisition of identity of their environment. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3422–3431, 2017." @default.
- W2751055561 created "2017-09-15" @default.
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- W2751055561 date "2017-09-26" @default.
- W2751055561 modified "2023-10-14" @default.
- W2751055561 title "Polyester vascular patches acquire arterial or venous identity depending on their environment" @default.
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- W2751055561 doi "https://doi.org/10.1002/jbm.a.36193" @default.
- W2751055561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5918420" @default.
- W2751055561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28877393" @default.