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- W2751069378 abstract "Abstract Objective: The aim of this study was to determine the association between chronic placental inflammation and amniotic fluid (AF) markers of maternal anti-fetal rejection as well as the presence of microorganisms in the AF fluid of patients with fetal death. Study Design: This cohort study included 40 patients with fetal death whose placentas were examined for chronic inflammatory lesions and whose AF chemokine ligand (CXCL)10 and interleukin (IL)-6 concentrations were determined by immunoassays. AF was processed for bacteria, mycoplasmas and viruses using cultivation and molecular microbiologic techniques (i.e. PCR-ESI/MS). Results: (1) The most prevalent placental findings were maternal vascular underperfusion (63.2%, 24/38), followed by chronic inflammatory lesions (57.9%, 22/38); (2) chronic chorioamnionitis (18/38) was three times more frequent than villitis of unknown etiology (6/38); (3) an elevated AF CXCL10 concentration (above the 95 th centile) was present in 60% of the cases, and a receiver operating characteristics (ROC)-derived cut-off of 2.9 ng/mL had a sensitivity of 73% and a specificity of 75% in the identification of chronic placental inflammatory lesions; (4) only five cases had microbial invasion of the amniotic cavity, and the presence of microorganisms did not correlate with chronic placental inflammation. Conclusion: In women with unexplained fetal death, there is an association between elevated AF CXCL10 and chronic placental inflammatory lesions. Therefore, we conclude that a subset of patients with fetal death may have endured a breakdown of maternal-fetal tolerance, which cannot be attributed to microorganisms in the amniotic cavity." @default.
- W2751069378 created "2017-09-15" @default.
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- W2751069378 date "2017-09-01" @default.
- W2751069378 modified "2023-10-18" @default.
- W2751069378 title "Fetal death: an extreme manifestation of maternal anti-fetal rejection" @default.
- W2751069378 cites W107282076 @default.
- W2751069378 cites W12722672 @default.
- W2751069378 cites W1489455139 @default.
- W2751069378 cites W1492784163 @default.
- W2751069378 cites W1507233500 @default.
- W2751069378 cites W1511621323 @default.
- W2751069378 cites W1521347358 @default.
- W2751069378 cites W1546770219 @default.
- W2751069378 cites W1548248319 @default.
- W2751069378 cites W1563950821 @default.
- W2751069378 cites W1590215829 @default.
- W2751069378 cites W1596901403 @default.
- W2751069378 cites W1655435601 @default.
- W2751069378 cites W1675122471 @default.
- W2751069378 cites W1676812023 @default.
- W2751069378 cites W1690408836 @default.
- W2751069378 cites W1699315466 @default.
- W2751069378 cites W17129754 @default.
- W2751069378 cites W1750459419 @default.
- W2751069378 cites W1753165172 @default.
- W2751069378 cites W1848934919 @default.
- W2751069378 cites W1851428995 @default.
- W2751069378 cites W1893553316 @default.
- W2751069378 cites W1931239063 @default.
- W2751069378 cites W1956703071 @default.
- W2751069378 cites W1963785041 @default.
- W2751069378 cites W1964610718 @default.
- W2751069378 cites W1964842863 @default.
- W2751069378 cites W1965863861 @default.
- W2751069378 cites W1966673624 @default.
- W2751069378 cites W1967054778 @default.
- W2751069378 cites W1969902629 @default.
- W2751069378 cites W1971739874 @default.
- W2751069378 cites W1973023139 @default.
- W2751069378 cites W197321688 @default.
- W2751069378 cites W1973318954 @default.
- W2751069378 cites W1974769266 @default.
- W2751069378 cites W1975724808 @default.
- W2751069378 cites W1976231198 @default.
- W2751069378 cites W1977652990 @default.
- W2751069378 cites W1978399330 @default.
- W2751069378 cites W1978819469 @default.
- W2751069378 cites W1979097615 @default.
- W2751069378 cites W1981424925 @default.
- W2751069378 cites W1982444915 @default.
- W2751069378 cites W1983206935 @default.
- W2751069378 cites W1983268079 @default.
- W2751069378 cites W1983378030 @default.
- W2751069378 cites W1983754013 @default.
- W2751069378 cites W1983889907 @default.
- W2751069378 cites W1984531139 @default.
- W2751069378 cites W1984726961 @default.
- W2751069378 cites W1984848787 @default.
- W2751069378 cites W1985671710 @default.
- W2751069378 cites W1985792473 @default.
- W2751069378 cites W1986223776 @default.
- W2751069378 cites W1986575495 @default.
- W2751069378 cites W1987384302 @default.
- W2751069378 cites W1989206432 @default.
- W2751069378 cites W1990818928 @default.
- W2751069378 cites W1990845589 @default.
- W2751069378 cites W1991056540 @default.
- W2751069378 cites W1991459122 @default.
- W2751069378 cites W1994565268 @default.
- W2751069378 cites W1994864933 @default.
- W2751069378 cites W1994929487 @default.
- W2751069378 cites W1995272947 @default.
- W2751069378 cites W1995900761 @default.
- W2751069378 cites W1996682463 @default.
- W2751069378 cites W1997512365 @default.
- W2751069378 cites W1998870778 @default.
- W2751069378 cites W1998872891 @default.
- W2751069378 cites W1999287272 @default.
- W2751069378 cites W2000296162 @default.
- W2751069378 cites W2003486765 @default.
- W2751069378 cites W2011716734 @default.
- W2751069378 cites W2012740474 @default.
- W2751069378 cites W2013493426 @default.
- W2751069378 cites W2014332109 @default.
- W2751069378 cites W2015260577 @default.