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- W2751247475 abstract "Objective To investigate the effect of venous pressure and different postures on platelet reactivity in patients with chronic venous insufficiency (CVI). Methods According to ncluded and excluded criteria, anticoagulated blood from superficial venous blood at the level of dorsum of foot and elbow was btained from 24 patients with CVI and 20 normal control subjects in different postures with or without simulated venous hypertension in vitro. The washed platelet plasma from anticoagulated blood samples was analyzed for P-selectin by enzyme-linked immuosorbent assay (ELISA). Results From supine position to standing position, there was no statistically significant variance in P-selectin of washed platelet plasma between different subjects ( P > 0. 05 ). After 60 min of simulated venous hypertension in vitro, whatever anticoagulated blood samples from superficial venous blood at the level of dorsum of foot or elbow, P-selectin from washed platelet plasma was significantly increased in patients with CVI as compared with normal control subjects (P < 0. 01 ). Conclusion Platelet hyper-reactivity in patients with CVI, resulted from venous hypertension, may play a major role in the pathogenesis of CVI.Key words: Platelet; Chronic venous insufficiency; Pathogenesis; Venous hypertension" @default.
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- W2751247475 date "2010-05-08" @default.
- W2751247475 modified "2023-09-27" @default.
- W2751247475 title "Effect of venous hypertension on platelet reactivity in patients with chronic venous insufficiency" @default.
- W2751247475 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2010.05.010" @default.
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