FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2751253882> ?p ?o ?g. }

• W2751253882 endingPage "486" @default.
• W2751253882 startingPage "481" @default.
• W2751253882 abstract "Acyl-CoA binding protein (ACBP) plays important roles in the metabolism of lipids in eukaryotic cells. In the industrially important filamentous fungus Aspergillus oryzae, although we have previously demonstrated that the A. oryzae ACBP (AoACBP) localizes to punctate structures and exhibits long-range motility, which is dependent on autophagy-related proteins, the physiological role of AoACBP remains elusive. Here, we describe identification and characterization of another ACBP from A. oryzae; we named this ACBP as AoAcb2 and accordingly renamed AoACBP as AoAcb1. The deduced amino acid sequence of AoAcb2 lacked a signal peptide. Phylogenetic analysis classified AoAcb2 into a clade that was same as the ACBP Acb1 of the model yeast Saccharomyces cerevisiae, but was different from that of AoAcb1. In contrast to punctate localization of AoAcb1, AoAcb2 was found to be dispersedly distributed in the cytoplasm, as was previously observed for the S. cerevisiae Acb1. Since we could not generate an Aoacb2 disruptant, we created an Aoacb2 conditional mutant that exhibited less growth under Aoacb2-repressed condition, suggesting that Aoacb2 is an essential gene for growth. Moreover, we observed that A. oryzae AoAcb2, but not A. oryzae AoAcb1, was secreted under carbon-starved condition, suggesting that AoAcb2 might be secreted via the unconventional protein secretion (UPS) pathway, just like S. cerevisiae Acb1. We also demonstrated that the unconventional secretion of AoAcb2 was dependent on the t-SNARE AoSso1, but was independent of the autophagy-related protein AoAtg1, suggesting that the unconventional secretion of AoAcb2, unlike that of S. cerevisiae Acb1, via the UPS pathway, is not regulated by the autophagy machinery. Thus, the filamentous fungus A. oryzae harbors two types of ACBPs, one of which appears to be essential for growth and undergoes unconventional secretion." @default.
• W2751253882 created "2017-09-15" @default.
• W2751253882 creator A5000940493 @default.
• W2751253882 creator A5007661756 @default.
• W2751253882 creator A5009561582 @default.
• W2751253882 creator A5053415843 @default.
• W2751253882 creator A5065871161 @default.
• W2751253882 creator A5066762322 @default.
• W2751253882 date "2017-11-01" @default.
• W2751253882 modified "2023-10-18" @default.
• W2751253882 title "Analysis of an acyl-CoA binding protein in Aspergillus oryzae that undergoes unconventional secretion" @default.
• W2751253882 cites W1540886471 @default.
• W2751253882 cites W1968182352 @default.
• W2751253882 cites W1981888655 @default.
• W2751253882 cites W1988206655 @default.
• W2751253882 cites W1988248986 @default.
• W2751253882 cites W1993690543 @default.
• W2751253882 cites W1999359085 @default.
• W2751253882 cites W2022920850 @default.
• W2751253882 cites W2026967084 @default.
• W2751253882 cites W2029553161 @default.
• W2751253882 cites W2033689828 @default.
• W2751253882 cites W2038634197 @default.
• W2751253882 cites W2061308761 @default.
• W2751253882 cites W2075043312 @default.
• W2751253882 cites W2080796421 @default.
• W2751253882 cites W2092441027 @default.
• W2751253882 cites W2102940990 @default.
• W2751253882 cites W2105304590 @default.
• W2751253882 cites W2105976996 @default.
• W2751253882 cites W2132146273 @default.
• W2751253882 cites W2214170075 @default.
• W2751253882 cites W2412379509 @default.
• W2751253882 cites W2529843534 @default.
• W2751253882 doi "https://doi.org/10.1016/j.bbrc.2017.08.166" @default.
• W2751253882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28870810" @default.
• W2751253882 hasPublicationYear "2017" @default.
• W2751253882 type Work @default.
• W2751253882 sameAs 2751253882 @default.
• W2751253882 citedByCount "11" @default.
• W2751253882 countsByYear W27512538822018 @default.
• W2751253882 countsByYear W27512538822019 @default.
• W2751253882 countsByYear W27512538822020 @default.
• W2751253882 countsByYear W27512538822021 @default.
• W2751253882 countsByYear W27512538822022 @default.
• W2751253882 countsByYear W27512538822023 @default.
• W2751253882 crossrefType "journal-article" @default.
• W2751253882 hasAuthorship W2751253882A5000940493 @default.
• W2751253882 hasAuthorship W2751253882A5007661756 @default.
• W2751253882 hasAuthorship W2751253882A5009561582 @default.
• W2751253882 hasAuthorship W2751253882A5053415843 @default.
• W2751253882 hasAuthorship W2751253882A5065871161 @default.
• W2751253882 hasAuthorship W2751253882A5066762322 @default.
• W2751253882 hasConcept C104317684 @default.
• W2751253882 hasConcept C10858879 @default.
• W2751253882 hasConcept C143065580 @default.
• W2751253882 hasConcept C167625842 @default.
• W2751253882 hasConcept C181199279 @default.
• W2751253882 hasConcept C190283241 @default.
• W2751253882 hasConcept C203522944 @default.
• W2751253882 hasConcept C2777576037 @default.
• W2751253882 hasConcept C2779222958 @default.
• W2751253882 hasConcept C2781204770 @default.
• W2751253882 hasConcept C49039625 @default.
• W2751253882 hasConcept C55493867 @default.
• W2751253882 hasConcept C86803240 @default.
• W2751253882 hasConcept C95444343 @default.
• W2751253882 hasConceptScore W2751253882C104317684 @default.
• W2751253882 hasConceptScore W2751253882C10858879 @default.
• W2751253882 hasConceptScore W2751253882C143065580 @default.
• W2751253882 hasConceptScore W2751253882C167625842 @default.
• W2751253882 hasConceptScore W2751253882C181199279 @default.
• W2751253882 hasConceptScore W2751253882C190283241 @default.
• W2751253882 hasConceptScore W2751253882C203522944 @default.
• W2751253882 hasConceptScore W2751253882C2777576037 @default.
• W2751253882 hasConceptScore W2751253882C2779222958 @default.
• W2751253882 hasConceptScore W2751253882C2781204770 @default.
• W2751253882 hasConceptScore W2751253882C49039625 @default.
• W2751253882 hasConceptScore W2751253882C55493867 @default.
• W2751253882 hasConceptScore W2751253882C86803240 @default.
• W2751253882 hasConceptScore W2751253882C95444343 @default.
• W2751253882 hasFunder F4320334764 @default.
• W2751253882 hasIssue "1" @default.
• W2751253882 hasLocation W27512538821 @default.
• W2751253882 hasLocation W27512538822 @default.
• W2751253882 hasOpenAccess W2751253882 @default.
• W2751253882 hasPrimaryLocation W27512538821 @default.
• W2751253882 hasRelatedWork W1971544440 @default.
• W2751253882 hasRelatedWork W2005628267 @default.
• W2751253882 hasRelatedWork W2017929146 @default.
• W2751253882 hasRelatedWork W2044415077 @default.
• W2751253882 hasRelatedWork W2058386431 @default.
• W2751253882 hasRelatedWork W2073003229 @default.
• W2751253882 hasRelatedWork W2080132193 @default.
• W2751253882 hasRelatedWork W2094282149 @default.
• W2751253882 hasRelatedWork W2751253882 @default.
• W2751253882 hasRelatedWork W2037515557 @default.
• W2751253882 hasVolume "493" @default.

• next