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- W2751282779 abstract "Significance There is increasing literature that links the overexpression of protein arginine methyltransferase (PRMT) 5 and PRMT7 to cancer metastasis and tumorigenesis and that suggests these enzymes may be good therapeutic targets. An important question remaining is how PRMT7 may control PRMT5 activity in mammalian cells. In this work, we demonstrate that PRMT7-dependent monomethylation at one site in histone H4 can activate another site for methylation by PRMT5. Such allosteric regulation has not been previously seen in this class of protein modification enzymes." @default.
- W2751282779 created "2017-09-15" @default.
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- W2751282779 date "2017-09-05" @default.
- W2751282779 modified "2023-10-12" @default.
- W2751282779 title "Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases" @default.
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- W2751282779 doi "https://doi.org/10.1073/pnas.1706978114" @default.
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