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• W2751324878 startingPage "463" @default.
• W2751324878 abstract "Epigenetics is defined as the study of the mechanisms that regulate gene expression without altering the underlying DNA sequence. The best known is DNA methylation. Multiple Sclerosis (MS) is a disease with no entirely known etiology, in which it is stated that the involvement of environmental factors on people with a genetic predisposition, may be key to the development of the disease. It is at this intersection between genetic predisposition and environmental factors where DNA methylation may play a pathogenic role.A literature review of the effects of environmental risk factors for the development of MS can have on the different epigenetic mechanisms as well as the implication that such changes have on the development of the disease.Knowledge of epigenetic modifications involved in the pathogenesis of MS, opens a new avenue of research for identification of potential biomarkers, as well as finding new therapeutic targets." @default.
• W2751324878 created "2017-09-15" @default.
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• W2751324878 date "2017-09-01" @default.
• W2751324878 modified "2023-10-16" @default.
• W2751324878 title "Modificaciones epigenéticas en neurología: alteraciones en la metilación del ADN en la esclerosis múltiple" @default.
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• W2751324878 doi "https://doi.org/10.1016/j.nrl.2015.03.011" @default.
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