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- W2751415342 abstract "Background: Globally, diabetes mellitus has become one of the most common serious diseases to public health. Mesenchymal stem cells provide an alternative option for treatment of diabetes. Objective: Investigation of adipose tissue-derived stem cells (AT-MSCs) potential as an available less invasive source to produce insulin producing cells (IPCs). Material and methods: Forty female and ten male adult rats of Sprague Dawley strain between 8-9 weeks-old weighing 150-200 g were used. The male rats were used as donors for mesenchymal stem cells, while female rats were assigned to four groups: Group I (control group), Group II (diabetic group), Group III (diabetic group injected by 2 doses of phosphate buffer saline) and Group IV (diabetic rats treated with MSCs isolated from adipose tissue). At the end of the experiment, serum levels of glucose, HbA1c, C-peptide and lipid profile, as well as the genes expressing the pancreatic regeneration (Pdx1 and Neuro D) were determined for all groups. The study was confirmed by histopathological and immunohistochemical examination of pancreatic tissue specimens. Results: STZinjection significantly increases the blood glucose, HbA1c, cholesterol, TG and LDL levels; while C-peptide and HDL levels significantly decreased. Furthermore, marked pancreatic destruction was also detected by significant decrease of pancreatic genes (Pdx1 and Neuro D) expression. All these parameters showed improvement with adipose tissue stem cells therapy. This improvement could not reach the normal levels when compared to the normal control group. These results were supported by the results of histological examination of pancreatic tissues. Conclusion: AT-MSCs therapy possessed anti-diabetogenic actions that might be mediated by their reducing effect on the blood glucose, HbA1c, lipid profile and expression of Pdx1 and Neuro D genes. The study demonstrated the potentiality of AT-MSCs as a safer, more promising source of IPCs providing a possible future therapeutic option for diabetes." @default.
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- W2751415342 date "2017-01-01" @default.
- W2751415342 modified "2023-09-23" @default.
- W2751415342 title "EFFECTS OF ADIPOSE TISSUE MESENCHYMAL STEM CELL THERAPY ON DIABETIC RATS" @default.
- W2751415342 doi "https://doi.org/10.12816/0035548" @default.
- W2751415342 hasPublicationYear "2017" @default.
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