Matches in SemOpenAlex for { <https://semopenalex.org/work/W2751481664> ?p ?o ?g. }
- W2751481664 endingPage "1353" @default.
- W2751481664 startingPage "1347" @default.
- W2751481664 abstract "•Triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein (HDL) cholesterol were increased in the overt hypothyroidism. •ApoA-I/II ratio, apoB, and apoE levels were elevated in the overt hypothyroidism. •All except HDL cholesterol and apoE levels recovered to baseline with levothyroxine therapy. •Cholesterol efflux and paraoxonase-1 activity decreased in the overt hypothyroidism. •Thyroid function affects HDL function and the levels of various lipid components. Background Thyroid hormone regulates lipid metabolism. In particular, it has been reported to regulate plasma high-density lipoprotein cholesterol (HDL-C) levels and the activity of molecules involved in HDL metabolism. Objective We investigated changes in the concentrations of lipids and apolipoproteins and in the function of HDL according to acute dynamic changes in thyroid function. Methods Concentrations of plasma lipids and apolipoproteins, paraoxonase-1 activity, and cholesterol efflux were measured in 27 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and radioactive iodine (RAI) treatment, at 3 distinct times: After surgery (baseline subclinical hyperthyroid state), on the day of undergoing RAI treatment (overt hypothyroid state), and 3 months post-RAI treatment (subclinical hyperthyroid state). Results The mean free T4 and thyroid-stimulating hormone concentrations were 0.24 ± 0.06 ng/dL and 91.2 (77.8–118.2) μIU/mL, respectively, on the day of RAI treatment. Total cholesterol, triglyceride, low-density lipoprotein cholesterol, and apoB levels, and the apoA-I/II ratio were significantly increased in the overt hypothyroid state and recovered to baseline values with levothyroxine replacement. HDL-C and apoE levels were persistently elevated despite levothyroxine replacement. Paraoxonase-1 activity, corrected for apoA-I, decreased in the overt hypothyroid state but recovered with levothyroxine replacement (P = .009). Cholesterol efflux also decreased significantly in the overt hypothyroid state (21.5 ± 5.1% vs 18.9 ± 2.9%, P = .005), but remained low despite recovery of thyroid function. Conclusion Changes in thyroid function are associated not only with changes in the concentrations of various plasma lipid components but also with changes in HDL function. Thyroid hormone regulates lipid metabolism. In particular, it has been reported to regulate plasma high-density lipoprotein cholesterol (HDL-C) levels and the activity of molecules involved in HDL metabolism. We investigated changes in the concentrations of lipids and apolipoproteins and in the function of HDL according to acute dynamic changes in thyroid function. Concentrations of plasma lipids and apolipoproteins, paraoxonase-1 activity, and cholesterol efflux were measured in 27 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and radioactive iodine (RAI) treatment, at 3 distinct times: After surgery (baseline subclinical hyperthyroid state), on the day of undergoing RAI treatment (overt hypothyroid state), and 3 months post-RAI treatment (subclinical hyperthyroid state). The mean free T4 and thyroid-stimulating hormone concentrations were 0.24 ± 0.06 ng/dL and 91.2 (77.8–118.2) μIU/mL, respectively, on the day of RAI treatment. Total cholesterol, triglyceride, low-density lipoprotein cholesterol, and apoB levels, and the apoA-I/II ratio were significantly increased in the overt hypothyroid state and recovered to baseline values with levothyroxine replacement. HDL-C and apoE levels were persistently elevated despite levothyroxine replacement. Paraoxonase-1 activity, corrected for apoA-I, decreased in the overt hypothyroid state but recovered with levothyroxine replacement (P = .009). Cholesterol efflux also decreased significantly in the overt hypothyroid state (21.5 ± 5.1% vs 18.9 ± 2.9%, P = .005), but remained low despite recovery of thyroid function. Changes in thyroid function are associated not only with changes in the concentrations of various plasma lipid components but also with changes in HDL function." @default.
- W2751481664 created "2017-09-15" @default.
- W2751481664 creator A5018433202 @default.
- W2751481664 creator A5023837417 @default.
- W2751481664 creator A5037206161 @default.
- W2751481664 creator A5049166863 @default.
- W2751481664 creator A5065930316 @default.
- W2751481664 creator A5084187574 @default.
- W2751481664 date "2017-11-01" @default.
- W2751481664 modified "2023-10-15" @default.
- W2751481664 title "Association between thyroid function and lipid profiles, apolipoproteins, and high-density lipoprotein function" @default.
- W2751481664 cites W1505641044 @default.
- W2751481664 cites W1970709107 @default.
- W2751481664 cites W1973349395 @default.
- W2751481664 cites W1976502787 @default.
- W2751481664 cites W1979779705 @default.
- W2751481664 cites W1980957923 @default.
- W2751481664 cites W1982111232 @default.
- W2751481664 cites W1989242866 @default.
- W2751481664 cites W1994339112 @default.
- W2751481664 cites W1996384429 @default.
- W2751481664 cites W2003509687 @default.
- W2751481664 cites W2009612186 @default.
- W2751481664 cites W2022622104 @default.
- W2751481664 cites W2026339220 @default.
- W2751481664 cites W2030365295 @default.
- W2751481664 cites W2032958076 @default.
- W2751481664 cites W2043015190 @default.
- W2751481664 cites W2057998225 @default.
- W2751481664 cites W2067073962 @default.
- W2751481664 cites W2075856178 @default.
- W2751481664 cites W2087975771 @default.
- W2751481664 cites W2090010489 @default.
- W2751481664 cites W2090982939 @default.
- W2751481664 cites W2091655302 @default.
- W2751481664 cites W2099733654 @default.
- W2751481664 cites W2129471240 @default.
- W2751481664 cites W2136770694 @default.
- W2751481664 cites W2144473676 @default.
- W2751481664 cites W2144962038 @default.
- W2751481664 cites W2146992882 @default.
- W2751481664 cites W2151736987 @default.
- W2751481664 cites W2165927667 @default.
- W2751481664 cites W2167540690 @default.
- W2751481664 cites W2169466388 @default.
- W2751481664 cites W2337072803 @default.
- W2751481664 cites W2413576220 @default.
- W2751481664 doi "https://doi.org/10.1016/j.jacl.2017.08.015" @default.
- W2751481664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28958565" @default.
- W2751481664 hasPublicationYear "2017" @default.
- W2751481664 type Work @default.
- W2751481664 sameAs 2751481664 @default.
- W2751481664 citedByCount "41" @default.
- W2751481664 countsByYear W27514816642018 @default.
- W2751481664 countsByYear W27514816642019 @default.
- W2751481664 countsByYear W27514816642020 @default.
- W2751481664 countsByYear W27514816642021 @default.
- W2751481664 countsByYear W27514816642022 @default.
- W2751481664 countsByYear W27514816642023 @default.
- W2751481664 crossrefType "journal-article" @default.
- W2751481664 hasAuthorship W2751481664A5018433202 @default.
- W2751481664 hasAuthorship W2751481664A5023837417 @default.
- W2751481664 hasAuthorship W2751481664A5037206161 @default.
- W2751481664 hasAuthorship W2751481664A5049166863 @default.
- W2751481664 hasAuthorship W2751481664A5065930316 @default.
- W2751481664 hasAuthorship W2751481664A5084187574 @default.
- W2751481664 hasConcept C126322002 @default.
- W2751481664 hasConcept C134018914 @default.
- W2751481664 hasConcept C2775883008 @default.
- W2751481664 hasConcept C2778163477 @default.
- W2751481664 hasConcept C2778913445 @default.
- W2751481664 hasConcept C2780072125 @default.
- W2751481664 hasConcept C2780541478 @default.
- W2751481664 hasConcept C2780745583 @default.
- W2751481664 hasConcept C2993291352 @default.
- W2751481664 hasConcept C526584372 @default.
- W2751481664 hasConcept C62746215 @default.
- W2751481664 hasConcept C71924100 @default.
- W2751481664 hasConceptScore W2751481664C126322002 @default.
- W2751481664 hasConceptScore W2751481664C134018914 @default.
- W2751481664 hasConceptScore W2751481664C2775883008 @default.
- W2751481664 hasConceptScore W2751481664C2778163477 @default.
- W2751481664 hasConceptScore W2751481664C2778913445 @default.
- W2751481664 hasConceptScore W2751481664C2780072125 @default.
- W2751481664 hasConceptScore W2751481664C2780541478 @default.
- W2751481664 hasConceptScore W2751481664C2780745583 @default.
- W2751481664 hasConceptScore W2751481664C2993291352 @default.
- W2751481664 hasConceptScore W2751481664C526584372 @default.
- W2751481664 hasConceptScore W2751481664C62746215 @default.
- W2751481664 hasConceptScore W2751481664C71924100 @default.
- W2751481664 hasIssue "6" @default.
- W2751481664 hasLocation W27514816641 @default.
- W2751481664 hasLocation W27514816642 @default.
- W2751481664 hasOpenAccess W2751481664 @default.
- W2751481664 hasPrimaryLocation W27514816641 @default.
- W2751481664 hasRelatedWork W1981848864 @default.
- W2751481664 hasRelatedWork W2012139915 @default.
- W2751481664 hasRelatedWork W2163567669 @default.