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- W2751531295 abstract "Organoid culture has had a significant impact on in vitro studies of the intestinal epithelium; however, the exquisite architecture, luminal accessibility, and lineage compartmentalization found in vivo has not been recapitulated in the organoid systems. We have used a microengineered platform with suitable extracellular matrix contacts and stiffness to generate a self-renewing mouse colonic epithelium that replicates key architectural and physiological functions found in vivo, including a surface lined with polarized crypts. Chemical gradients applied to the basal–luminal axis compartmentalized the stem/progenitor cells and promoted appropriate lineage differentiation along the in vitro crypt axis so that the tissue possessed a crypt stem cell niche as well as a layer of differentiated cells covering the luminal surface. This new approach combining microengineered scaffolds, native chemical gradients, and biophysical cues to control primary epithelium ex vivo can serve as a highly functional and physiologically relevant in vitro tissue model." @default.
- W2751531295 created "2017-09-15" @default.
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- W2751531295 date "2017-09-13" @default.
- W2751531295 modified "2023-10-14" @default.
- W2751531295 title "<i>In Vitro</i> Generation of Mouse Colon Crypts" @default.
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- W2751531295 doi "https://doi.org/10.1021/acsbiomaterials.7b00368" @default.
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