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- W2751539072 abstract "Objective To investigate the relationship between the expression of B7-H3 and the level of tumor-associated macrophages’(TAMs) infiltration in hepatocellular carcinoma(HCC) tissues. Methods The expression level of B7-H3 was detected by immunohistochemistry and quantitative Real-time PCR in 116 HCC tissues. Immunohistochemistry also was used to detect CD68 ex-pression. Then the relationship between B7-H3, CD68 expression and clinicopathologic features was analyzed. Results Among the 116 cancer tissues, the high expression rate of B7-H3 was 79. 3%( 92/116);and patients with the low, middle, high level of TAMs infil-tration were 21, 49 and 46 cases. The expression of B7-H3 was related to TNM stage, vascular invasion and microsatellite lesions for-mation( P<0. 05);The level of TAMs infiltration was related to TNM stage, vascular invasion, lymph node metastases and microsatel-lite lesions formation( P<0. 05) . The mRNA level of B7-H3 was significantly correlated with the level of TAMs infiltration ( r=0. 473,P<0. 001) . Conclusion The expression level of B7-H3 is positively correlated with the level of TAMs infiltration in HCC tissues, and they may contribute to the oncogenesis and progression of HCC." @default.
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- W2751539072 date "2016-01-01" @default.
- W2751539072 modified "2023-09-26" @default.
- W2751539072 title "Correlation analysis between the expression of B7-H3 and the level of macrophages infiltration in hepatocel-lular carcinoma tissues" @default.
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