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- W2751597085 abstract "X-ray crystallographic characterization of enzymes at different stages in their reaction cycles can provide unique insight into the reaction pathway, the number and type of intermediates formed, and their structural context. The known mechanistic diversity in the radical S-adenosylmethionine (SAM) superfamily of enzymes makes it an appealing target for such studies as more than 100,000 sequences have been identified to date with wide-ranging reactivities that share a pattern of complex radical-mediated chemistry. Here, we review selected examples of radical SAM enzyme crystal structures representative of reactant, product, and intermediate state complexes with a particular emphasis on the strategies employed to capture these states. Broader application of structural characterization techniques to analyze mechanism and substrate specificity is certain to play an important role as more members of this family become tractable for biochemical study." @default.
- W2751597085 created "2017-09-15" @default.
- W2751597085 creator A5039479636 @default.
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- W2751597085 date "2017-01-01" @default.
- W2751597085 modified "2023-09-27" @default.
- W2751597085 title "Mechanism-Based Strategies for Structural Characterization of Radical SAM Reaction Intermediates" @default.
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- W2751597085 doi "https://doi.org/10.1016/bs.mie.2017.07.008" @default.
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