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- W2751731131 abstract "<b><i>Aim:</i></b> The objective of this study was to investigate a possible correlation between the plasminogen activator inhibitor-1 (PAI-1) and methylene tetrahydrofolate reductase (MTHFR) polymorphisms and unexplained spontaneous miscarriages (SM). <b><i>Materials and Methods:</i></b> PAI-1 polymorphisms were evaluated in 150 women with pregnancy in their history. One hundred women with a history of SM formed the study group and 50 women with normal pregnancies served as the control group. Also, the combination of PAI-1 and MTHFR polymorphisms were evaluated in 138 women out of a total of 150, which included 92 women with SM in their history compared to 46 women in the control group. For statistical analysis, χ<sup>2</sup> test, Phi, and Cramer V tests were used; <i>p</i> < 0.05 was taken as a statistically significant result. <b><i>Results:</i></b> Our findings show: (a) the correlation between SM and PAI-1 mutations reaches statistical significance (<i>p</i> = 0.026); (b) there was a statistically significant difference between heterozygous PAI-1 in women with only 1 SM compared to the control group (<i>p</i> = 0.047); (c) the comparison of combinations of both mutations, PAI-1 and MTHFR, with the control group demonstrates statistical significance in favor of women with SM and both mutations (<i>p</i> = 0.022). <b><i>Conclusion:</i></b> PAI-1 and MTHFR polymorphisms may play an important role in pregnancy complications because heterozygous PAI-1 mutations and a combination of both PAI-1 and MTHFR mutations might contribute to SM." @default.
- W2751731131 created "2017-09-15" @default.
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- W2751731131 date "2017-01-01" @default.
- W2751731131 modified "2023-10-16" @default.
- W2751731131 title "Association of Plasminogen Activator Inhibitor-1 Gene Polymorphisms and Methylene Tetrahydrofolate Reductase Polymorphisms with Spontaneous Miscarriages" @default.
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- W2751731131 doi "https://doi.org/10.1159/000478084" @default.
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