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• W2751740351 abstract "Abstract Microseminoprotein-beta (MSMB) is one of the most abundant proteins in human seminal plasma. The current study was aimed to assess the impact of MSMB rs10993994, rs12770171, rs10994385 variants on prostate cancer (PCa) risk in a sample of Iranian population. This case-control study was executed on 169 pathologically confirmed PCa patients and 182 benign prostatic hyperplasia (BPH). Genotyping was performed by using the PCR-RFLP method. Our findings showed that rs10993994 variant significantly increased the risk of PCa in codominant (OR = 1.64, 95%CI = 1.04–2.59, P = 0.038, CT vs TT) and overdominant (OR = 1.64, 95%CI = 1.03–2.43, P = 0.039, TC vs TT + CC) models. However, no significant association was observed among rs10994385 G > C and rs12770171 C > T polymorphisms and PCa risk. In summary, the findings showed that MSMB rs10993994 polymorphism increased the risk of PCa in an Iranian population. To verify our findings, well-designed studies with larger sample sizes and representing various ethnicities are needed." @default.
• W2751740351 created "2017-09-15" @default.
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• W2751740351 date "2017-12-01" @default.
• W2751740351 modified "2023-09-27" @default.
• W2751740351 title "The rs10993994 functional polymorphism in the MSMB gene promoter increase the risk of prostate cancer in an Iranian population" @default.
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• W2751740351 doi "https://doi.org/10.1016/j.mgene.2017.08.011" @default.
• W2751740351 hasPublicationYear "2017" @default.
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