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• W2751762869 abstract "Developmental remodeling of the sensory epithelium of the cochlea is required for the formation of an elongated, tonotopically organized auditory organ, but the cellular processes that mediate these events are largely unknown. Therefore, we used both morphological assessments of cellular rearrangements and time-lapse imaging to visualize cochlear remodeling. Analysis of cell redistribution showed that the cochlea extends through a combination of radial intercalation and cell growth. Live imaging demonstrated that concomitant cellular intercalation results in a brief period of epithelial convergence, although subsequent changes in cell size lead to medial-lateral spreading. Supporting cells, which retain contact with the basement membrane, exhibit biased protrusive activity and directed movement along the axis of extension. In contrast, hair cells lose contact with the basement membrane, but contribute to continued outgrowth through increased cell size. Regulation of cellular protrusions, movement, and intercalation within the cochlea all require Myosin II. The results establish, for the first time, many of the cellular processes that drive the distribution of sensory cells along the tonotopic axis of the cochlea." @default.
• W2751762869 created "2017-09-15" @default.
• W2751762869 creator A5001974165 @default.
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• W2751762869 date "2017-01-01" @default.
• W2751762869 modified "2023-10-18" @default.
• W2751762869 title "Cell migration, intercalation, and growth regulates mammalian cochlear extension" @default.
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• W2751762869 doi "https://doi.org/10.1242/dev.151761" @default.
• W2751762869 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5675446" @default.
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