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- W2751773735 abstract "Dihydropyridines derivative have been synthesized by one-pot multicomponent cyclocondensation reaction using PBI-PPh3 catalyst. This catalyst is characterized by the solid state of 13C-NMR, 15N-NMR, and 31P-NMR spectrum, FT-IR, cyclic voltammetry, and XRD analysis. The selection of catalyst is quite interesting because of its affordability, toxic free nature and high stability. Functional groups of all dihydropyridines confirms by H1-NMR and FTIR spectra. Synthesized compounds show exceptional yields of 96–99 %. Synthesized compounds has evaluated for their invitro antibacterial activity against B. subtilis, and P. vulgaris (ATCC 49565) and C. albicans (ATCC 90028). Synthesized dihydropyridines showed promising antibacterial and antifungal activities, in particularly, ethyl-4-(4-methylphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexadihydropyridine-3-carboxylate are exhibiting a higher inhibition zone of 66.7 % against bacteria. Our method may help to drug chemists for design more interesting, useful, and sustainable reactions in the near future." @default.
- W2751773735 created "2017-09-15" @default.
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- W2751773735 date "2017-08-31" @default.
- W2751773735 modified "2023-09-22" @default.
- W2751773735 title "Polybenzimidazole-Triphenylphosphene-Catalyzed One-Pot Synthesis and Evaluation of Dihydropyridine Derivative as Antibiotics and Antifungals" @default.
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- W2751773735 doi "https://doi.org/10.1002/slct.201700918" @default.
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