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• W2751792648 abstract "Childhood malnutrition is a risk factor for mental disorders, such as major depression and anxiety. Evidence shows that similar early life adversities induce sex-dependent epigenetic reprogramming. However, little is known about how genes are specifically affected by early malnutrition and the implications for males and females respectively. One relevant target is neuropeptide Y (NPY), which regulates both stress and food-intake. We studied maternal low protein diet (LPD) during pregnancy/lactation in mice. Male, but not female, offspring of LPD mothers consistently displayed anxiety- and depression-like behaviors under acute stress. Transcriptome-wide analysis of the effects of acute stress in the amygdala, revealed a list of transcription factors affected by either sex or perinatal LPD. Among these immediate early genes (IEG), members of the Early growth response family (Egr1/2/4) were consistently upregulated by perinatal LPD in both sexes. EGR1 also bound the NPY receptor Y1 gene (Npy1r), which co-occurred with sex-specific effects of perinatal LPD on both Npy1r DNA-methylation and gene transcription. Our proposed pathway connecting early malnutrition, sex-independent regulatory changes in Egr1, and sex-specific epigenetic reprogramming of its effector gene, Npy1r, represents the first molecular evidence of how early life risk factors may generate sex-specific epigenetic effects relevant for mental disorders." @default.
• W2751792648 created "2017-09-15" @default.
• W2751792648 creator A5011686215 @default.
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• W2751792648 date "2017-09-11" @default.
• W2751792648 modified "2023-10-06" @default.
• W2751792648 title "Perinatal Malnutrition Leads to Sexually Dimorphic Behavioral Responses with Associated Epigenetic Changes in the Mouse Brain" @default.
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• W2751792648 doi "https://doi.org/10.1038/s41598-017-10803-2" @default.
• W2751792648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5593991" @default.
• W2751792648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28894112" @default.
• W2751792648 hasPublicationYear "2017" @default.
• W2751792648 type Work @default.
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