FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2751837488> ?p ?o ?g. }

• W2751837488 endingPage "2909" @default.
• W2751837488 startingPage "2896" @default.
• W2751837488 abstract "Abstract Sensing of cytosolic nucleotides is a critical initial step in the elaboration of type I IFN. One of several upstream receptors, cyclic GMP–AMP synthase, binds to cytosolic DNA and generates dicyclic nucleotides that act as secondary messengers. These secondary messengers bind directly to stimulator of IFN genes (STING). STING recruits TNFR-associated NF-κB kinase–binding kinase 1 which acts as a critical node that allows for efficient activation of IFN regulatory factors to drive the antiviral transcriptome. NLRC3 is a recently characterized nucleotide-binding domain, leucine-rich repeat containing protein (NLR) that negatively regulates the type I IFN pathway by inhibiting subcellular redistribution and effective signaling of STING, thus blunting the transcription of type I IFNs. NLRC3 is predominantly expressed in lymphoid and myeloid cells. IQGAP1 was identified as a putative interacting partner of NLRC3 through yeast two-hybrid screening. In this article, we show that IQGAP1 associates with NLRC3 and can disrupt the NLRC3–STING interaction in the cytosol of human epithelial cells. Furthermore, knockdown of IQGAP1 in THP1 and HeLa cells causes significantly more IFN-β production in response to cytosolic nucleic acids. This result phenocopies NLRC3-deficient macrophages and fibroblasts and short hairpin RNA knockdown of NLRC3 in THP1 cells. Our findings suggest that IQGAP1 is a novel regulator of type I IFN production, possibly via interacting with NLRC3 in human monocytic and epithelial cells." @default.
• W2751837488 created "2017-09-15" @default.
• W2751837488 creator A5008822197 @default.
• W2751837488 creator A5041958759 @default.
• W2751837488 creator A5050217489 @default.
• W2751837488 creator A5066273113 @default.
• W2751837488 creator A5069768827 @default.
• W2751837488 creator A5080753932 @default.
• W2751837488 creator A5085029842 @default.
• W2751837488 creator A5085051802 @default.
• W2751837488 date "2017-10-15" @default.
• W2751837488 modified "2023-10-16" @default.
• W2751837488 title "The Scaffolding Protein IQGAP1 Interacts with NLRC3 and Inhibits Type I IFN Production" @default.
• W2751837488 cites W1559117436 @default.
• W2751837488 cites W1559677484 @default.
• W2751837488 cites W1585737615 @default.
• W2751837488 cites W1594921148 @default.
• W2751837488 cites W1667606852 @default.
• W2751837488 cites W1798681852 @default.
• W2751837488 cites W1897605380 @default.
• W2751837488 cites W1966132440 @default.
• W2751837488 cites W1968178474 @default.
• W2751837488 cites W1969354039 @default.
• W2751837488 cites W1970154782 @default.
• W2751837488 cites W1973455657 @default.
• W2751837488 cites W1973880082 @default.
• W2751837488 cites W1975374700 @default.
• W2751837488 cites W1983411723 @default.
• W2751837488 cites W1983924398 @default.
• W2751837488 cites W1985643113 @default.
• W2751837488 cites W1986303112 @default.
• W2751837488 cites W1986503317 @default.
• W2751837488 cites W1987433340 @default.
• W2751837488 cites W1991982546 @default.
• W2751837488 cites W2000023984 @default.
• W2751837488 cites W2000564866 @default.
• W2751837488 cites W2003034886 @default.
• W2751837488 cites W2004776380 @default.
• W2751837488 cites W2010839055 @default.
• W2751837488 cites W2011856953 @default.
• W2751837488 cites W2012034410 @default.
• W2751837488 cites W2013999310 @default.
• W2751837488 cites W2014011959 @default.
• W2751837488 cites W2016771009 @default.
• W2751837488 cites W2024209312 @default.
• W2751837488 cites W2031113436 @default.
• W2751837488 cites W2033853755 @default.
• W2751837488 cites W2044330780 @default.
• W2751837488 cites W2053352311 @default.
• W2751837488 cites W2055063197 @default.
• W2751837488 cites W2057101841 @default.
• W2751837488 cites W2057372272 @default.
• W2751837488 cites W2060441844 @default.
• W2751837488 cites W2061042417 @default.
• W2751837488 cites W2065568171 @default.
• W2751837488 cites W2067436737 @default.
• W2751837488 cites W2068844394 @default.
• W2751837488 cites W2069917993 @default.
• W2751837488 cites W2070176615 @default.
• W2751837488 cites W2070412403 @default.
• W2751837488 cites W2070461642 @default.
• W2751837488 cites W2075860675 @default.
• W2751837488 cites W2079744030 @default.
• W2751837488 cites W2085013781 @default.
• W2751837488 cites W2088157683 @default.
• W2751837488 cites W2093268266 @default.
• W2751837488 cites W2097035469 @default.
• W2751837488 cites W2101096291 @default.
• W2751837488 cites W2105409495 @default.
• W2751837488 cites W2109745607 @default.
• W2751837488 cites W2110723933 @default.
• W2751837488 cites W2116527093 @default.
• W2751837488 cites W2119249844 @default.
• W2751837488 cites W2119756816 @default.
• W2751837488 cites W2119864130 @default.
• W2751837488 cites W2126826389 @default.
• W2751837488 cites W2128190429 @default.
• W2751837488 cites W2132490889 @default.
• W2751837488 cites W2133006561 @default.
• W2751837488 cites W2133402546 @default.
• W2751837488 cites W2142433291 @default.
• W2751837488 cites W2143475407 @default.
• W2751837488 cites W2148581259 @default.
• W2751837488 cites W2150715314 @default.
• W2751837488 cites W2160790198 @default.
• W2751837488 cites W2233529118 @default.
• W2751837488 cites W2293064726 @default.
• W2751837488 cites W2339086935 @default.
• W2751837488 cites W2339772124 @default.
• W2751837488 cites W2342218776 @default.
• W2751837488 cites W2407136405 @default.
• W2751837488 cites W2409988635 @default.
• W2751837488 cites W2430748732 @default.
• W2751837488 cites W2461543056 @default.
• W2751837488 cites W2469317767 @default.
• W2751837488 cites W2473781670 @default.
• W2751837488 cites W2494587789 @default.
• W2751837488 cites W2560628550 @default.

• next