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• W2751844130 abstract "This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide trehalose in the Tg2576 transgenic mouse model of Alzheimer's disease (AD) via an oral gavage of a 2% trehalose solution for 31 days. Furthermore, as AD is a neurodegenerative condition in which the transition metals, iron, copper, and zinc, are understood to be intricately involved in the cellular cascades leading to the defining pathologies of the disease, we sought to determine any parallel impact of trehalose treatment on metal levels. Trehalose treatment significantly improved performance in the Morris water maze, consistent with enhanced learning and memory. The improvement was not associated with significant modulation of full length amyloid-β protein precursor or other amyloid-β fragments. Trehalose had no effect on autophagy as assessed by western blot of the LC3-1 to LC3-2 protein ratio, and no alteration in biometals that might account for the improved cognition was observed. Biochemical analysis revealed a significant increase in the hippocampus of both synaptophysin, a synaptic vesicle protein and surrogate marker of synapses, and doublecortin, a reliable marker of neurogenesis. The growth factor progranulin was also significantly increased in the hippocampus and cortex with trehalose treatment. This study suggests that trehalose might invoke a suite of neuroprotective mechanisms that can contribute to improved cognitive performance in AD that are independent of more classical trehalose-mediated pathways, such as Aβ reduction and activation of autophagy. Thus, trehalose may have utility as a potential AD therapeutic, with conceivable implications for the treatment of other neurodegenerative disorders." @default.
• W2751844130 created "2017-09-15" @default.
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• W2751844130 date "2017-09-18" @default.
• W2751844130 modified "2023-10-14" @default.
• W2751844130 title "Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer’s Disease" @default.
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• W2751844130 cites W1966113514 @default.
• W2751844130 cites W1968763345 @default.
• W2751844130 cites W1970503230 @default.
• W2751844130 cites W1975404052 @default.
• W2751844130 cites W1985621776 @default.
• W2751844130 cites W1986346910 @default.
• W2751844130 cites W1988650085 @default.
• W2751844130 cites W1991039509 @default.
• W2751844130 cites W1992527609 @default.
• W2751844130 cites W1992641430 @default.
• W2751844130 cites W1998735201 @default.
• W2751844130 cites W2006129024 @default.
• W2751844130 cites W2007471517 @default.
• W2751844130 cites W2008197060 @default.
• W2751844130 cites W2011928186 @default.
• W2751844130 cites W2014520750 @default.
• W2751844130 cites W2015640433 @default.
• W2751844130 cites W2018463430 @default.
• W2751844130 cites W2019034135 @default.
• W2751844130 cites W2019279182 @default.
• W2751844130 cites W2019320660 @default.
• W2751844130 cites W2025615265 @default.
• W2751844130 cites W2030667534 @default.
• W2751844130 cites W2032296063 @default.
• W2751844130 cites W2033229501 @default.
• W2751844130 cites W2039517040 @default.
• W2751844130 cites W2043147243 @default.
• W2751844130 cites W2044537731 @default.
• W2751844130 cites W2044771093 @default.
• W2751844130 cites W2048061357 @default.
• W2751844130 cites W2051516838 @default.
• W2751844130 cites W2055659156 @default.
• W2751844130 cites W2057127239 @default.
• W2751844130 cites W2057220764 @default.
• W2751844130 cites W2057698260 @default.
• W2751844130 cites W2065006491 @default.
• W2751844130 cites W2067260963 @default.
• W2751844130 cites W2069856306 @default.
• W2751844130 cites W2072382154 @default.
• W2751844130 cites W2077696887 @default.
• W2751844130 cites W2083500052 @default.
• W2751844130 cites W2084174305 @default.
• W2751844130 cites W2086723383 @default.
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• W2751844130 cites W2095993418 @default.
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• W2751844130 cites W2171750058 @default.
• W2751844130 cites W2293737369 @default.
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• W2751844130 doi "https://doi.org/10.3233/jad-170322" @default.
• W2751844130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5611803" @default.
• W2751844130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28869469" @default.
• W2751844130 hasPublicationYear "2017" @default.
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