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- W2751851851 abstract "This chapter focuses on the nuclear receptor VDR and its target genes. Transcriptional regulation is a central process for nearly all physiological actions in eukaryotes. The sequencing of the complete human genome and the genomes of other species, i.e. the availability of all regulatory sequences, enable a more mature understanding of the diversity of 1,25(OH)2D3 target genes. Perhaps the idea of simple isolated VDREs should shift to the concept of complex VDREs, of which the simple VDRE represents the core. Depending on the temporal presence of cell-specific transcription factors, these complex REs may act positively or negatively in respect to 1,25(OH)2D3. The coordinated action of these different types of VDREs could explain the individual response of target genes to 1,25(OH)2D3. Methods incorporating both experimental- and informatics-derived evidence to arrive at a more reliable prediction of VDR targets and binding modules can bring all available data together with the ultimate aim to predict the outcome in a specific context. One can envision that in the future, the emphasis will shift from target genes to target regulatory modules to alter a physiological response and from individual genes to whole-genome response. Therefore, a much larger challenge lies ahead where scientists will be confronted with the higher order of regulated networks of genes, where the sum effect of ligand treatment may be defined." @default.
- W2751851851 created "2017-09-15" @default.
- W2751851851 creator A5035613777 @default.
- W2751851851 date "2011-01-01" @default.
- W2751851851 modified "2023-09-27" @default.
- W2751851851 title "Target Genes of Vitamin D" @default.
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