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- W2751932890 abstract "The norepinephrine transporter (NET) is essential for norepinephrine uptake at the synaptic terminals and adrenal chromaffin cells. In neuroendocrine tumors, NET can be targeted for imaging as well as therapy. One of the most widely used theranostic agents targeting NET is metaiodobenzylguanidine (MIBG), a guanethidine analog of norepinephrine. 123I/131I-MIBG theranostics have been applied in the clinical evaluation and management of neuroendocrine tumors, especially in neuroblastoma, paraganglioma, and pheochromocytoma. 123I-MIBG imaging is a mainstay in the evaluation of neuroblastoma, and 131I-MIBG has been used for the treatment of relapsed high-risk neuroblastoma for several years, however, the outcome remains suboptimal. 131I-MIBG has essentially been only palliative in paraganglioma/pheochromocytoma patients. Various techniques of improving therapeutic outcomes, such as dosimetric estimations, high-dose therapies, multiple fractionated administration and combination therapy with radiation sensitizers, chemotherapy, and other radionuclide therapies, are being evaluated. PET tracers targeting NET appear promising and may be more convenient options for the imaging and assessment after treatment. Here, we present an overview of NET as a target for theranostics; review its current role in some neuroendocrine tumors, such as neuroblastoma, paraganglioma/pheochromocytoma, and carcinoids; and discuss approaches to improving targeting and theranostic outcomes." @default.
- W2751932890 created "2017-09-15" @default.
- W2751932890 creator A5010076893 @default.
- W2751932890 creator A5050680844 @default.
- W2751932890 date "2017-09-01" @default.
- W2751932890 modified "2023-10-13" @default.
- W2751932890 title "Norepinephrine Transporter as a Target for Imaging and Therapy" @default.
- W2751932890 cites W1101533912 @default.
- W2751932890 cites W1553241524 @default.
- W2751932890 cites W1572629057 @default.
- W2751932890 cites W1890108413 @default.
- W2751932890 cites W1894683927 @default.
- W2751932890 cites W1919038564 @default.
- W2751932890 cites W1933402771 @default.
- W2751932890 cites W1944076654 @default.
- W2751932890 cites W1965773171 @default.
- W2751932890 cites W1966893598 @default.
- W2751932890 cites W1967988534 @default.
- W2751932890 cites W1968058785 @default.
- W2751932890 cites W1969319676 @default.
- W2751932890 cites W1971404503 @default.
- W2751932890 cites W1971596734 @default.
- W2751932890 cites W1972699307 @default.
- W2751932890 cites W1973422796 @default.
- W2751932890 cites W1974076424 @default.
- W2751932890 cites W1977737779 @default.
- W2751932890 cites W1978831817 @default.
- W2751932890 cites W1979656335 @default.
- W2751932890 cites W1980516021 @default.
- W2751932890 cites W1980627618 @default.
- W2751932890 cites W1981618893 @default.
- W2751932890 cites W1982238493 @default.
- W2751932890 cites W1982294823 @default.
- W2751932890 cites W1983159532 @default.
- W2751932890 cites W1986724401 @default.
- W2751932890 cites W1986876870 @default.
- W2751932890 cites W1991259883 @default.
- W2751932890 cites W1996523908 @default.
- W2751932890 cites W1998251917 @default.
- W2751932890 cites W1998858645 @default.
- W2751932890 cites W1999805371 @default.
- W2751932890 cites W2001972938 @default.
- W2751932890 cites W2005446804 @default.
- W2751932890 cites W2011891156 @default.
- W2751932890 cites W2015385940 @default.
- W2751932890 cites W2017954660 @default.
- W2751932890 cites W2021125923 @default.
- W2751932890 cites W2026297667 @default.
- W2751932890 cites W2028374130 @default.
- W2751932890 cites W2028874318 @default.
- W2751932890 cites W2029590939 @default.
- W2751932890 cites W2033305913 @default.
- W2751932890 cites W2035434808 @default.
- W2751932890 cites W2035594058 @default.
- W2751932890 cites W2039362801 @default.
- W2751932890 cites W2042750219 @default.
- W2751932890 cites W2044485671 @default.
- W2751932890 cites W2046209641 @default.
- W2751932890 cites W2046291757 @default.
- W2751932890 cites W2051488635 @default.
- W2751932890 cites W2052024706 @default.
- W2751932890 cites W2053086073 @default.
- W2751932890 cites W2054524692 @default.
- W2751932890 cites W2055454912 @default.
- W2751932890 cites W2056762938 @default.
- W2751932890 cites W2057968331 @default.
- W2751932890 cites W2059844864 @default.
- W2751932890 cites W2059949901 @default.
- W2751932890 cites W2060218822 @default.
- W2751932890 cites W2061932798 @default.
- W2751932890 cites W2064520485 @default.
- W2751932890 cites W2067601106 @default.
- W2751932890 cites W2069033623 @default.
- W2751932890 cites W2069773127 @default.
- W2751932890 cites W2069976764 @default.
- W2751932890 cites W2070506138 @default.
- W2751932890 cites W2070550035 @default.
- W2751932890 cites W2072069204 @default.
- W2751932890 cites W2077239542 @default.
- W2751932890 cites W2077242620 @default.
- W2751932890 cites W2082495591 @default.
- W2751932890 cites W2083026262 @default.
- W2751932890 cites W2083272432 @default.
- W2751932890 cites W2083873064 @default.
- W2751932890 cites W2084557904 @default.
- W2751932890 cites W2085376116 @default.
- W2751932890 cites W2085768796 @default.
- W2751932890 cites W2087589038 @default.
- W2751932890 cites W2088421797 @default.
- W2751932890 cites W2091158789 @default.
- W2751932890 cites W2091691417 @default.
- W2751932890 cites W2094044799 @default.
- W2751932890 cites W2095058352 @default.
- W2751932890 cites W2096506747 @default.
- W2751932890 cites W2098908781 @default.
- W2751932890 cites W2099616311 @default.
- W2751932890 cites W2101598041 @default.
- W2751932890 cites W2104684902 @default.