FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2752035137> ?p ?o ?g. }

• W2752035137 endingPage "292" @default.
• W2752035137 startingPage "283" @default.
• W2752035137 abstract "G-protein-coupled estrogen receptor (GPER) was found to promote non-small cell lung cancer (NSCLC) by estrogen, indicating the potential necessity of inhibiting GPER by a selective antagonist. This study was performed to elucidate the function of GPER-selective inhibitor G15 in NSCLC development. Cytoplasmic GPER (cGPER) and nuclear GPER (nGPER) were detected by immunohistochemical analysis in NSCLC samples. The relation of GPER and estrogen receptor β (ERβ) expression and correlation between GPER, ERβ, and clinical factors were analyzed. The effects of activating GPER and function of G15 were analyzed in the proliferation of A549 and H1793 cell lines and development of urethane-induced adenocarcinoma. Overexpression of cGPER and nGPER was detected in 80.49% (120/150) and 52.00% (78/150) of the NSCLC samples. High expression of GPER was related with higher stages, poorer differentiation, and high expression of ERβ. The protein level of GPER in the A549 and H1793 cell lines was increased by treatment with E2, G1 (GPER agonist), or fulvestrant (Ful; ERβ antagonist) and decreased by G15. Administration with G15 reversed the E2- or G1-induced cell growth by inhibiting GPER. In urethane-induced adenocarcinoma mice, the number of tumor nodules and tumor index increased in the E2 or G1 group and decreased by treatment with G15. These findings demonstrate that using G15 to block GPER signaling may be considered as a new therapeutic target in NSCLC." @default.
• W2752035137 created "2017-09-15" @default.
• W2752035137 creator A5003962764 @default.
• W2752035137 creator A5019502581 @default.
• W2752035137 creator A5028414570 @default.
• W2752035137 creator A5029584046 @default.
• W2752035137 creator A5080703203 @default.
• W2752035137 creator A5082019218 @default.
• W2752035137 creator A5084029581 @default.
• W2752035137 creator A5084190227 @default.
• W2752035137 date "2019-02-21" @default.
• W2752035137 modified "2023-10-02" @default.
• W2752035137 title "G-Protein-Coupled Estrogen Receptor Antagonist G15 Decreases Estrogen-Induced Development of Non-Small Cell Lung Cancer" @default.
• W2752035137 cites W1550021021 @default.
• W2752035137 cites W1978363604 @default.
• W2752035137 cites W1979473121 @default.
• W2752035137 cites W1981467972 @default.
• W2752035137 cites W1984948100 @default.
• W2752035137 cites W1996673634 @default.
• W2752035137 cites W2001882859 @default.
• W2752035137 cites W2005401913 @default.
• W2752035137 cites W2011770154 @default.
• W2752035137 cites W2019252018 @default.
• W2752035137 cites W2024344832 @default.
• W2752035137 cites W2027286015 @default.
• W2752035137 cites W2034001757 @default.
• W2752035137 cites W2037790468 @default.
• W2752035137 cites W2052024663 @default.
• W2752035137 cites W2071059074 @default.
• W2752035137 cites W2071993616 @default.
• W2752035137 cites W2074875734 @default.
• W2752035137 cites W2075443461 @default.
• W2752035137 cites W2076908209 @default.
• W2752035137 cites W2087377669 @default.
• W2752035137 cites W2092184448 @default.
• W2752035137 cites W2095200029 @default.
• W2752035137 cites W2098789166 @default.
• W2752035137 cites W2107497260 @default.
• W2752035137 cites W2108014187 @default.
• W2752035137 cites W2122015809 @default.
• W2752035137 cites W2124252848 @default.
• W2752035137 cites W2130606388 @default.
• W2752035137 cites W2137681063 @default.
• W2752035137 cites W2138899155 @default.
• W2752035137 cites W2140897623 @default.
• W2752035137 cites W2141130185 @default.
• W2752035137 cites W2161118254 @default.
• W2752035137 cites W2164804511 @default.
• W2752035137 cites W2283559195 @default.
• W2752035137 doi "https://doi.org/10.3727/096504017x15035795904677" @default.
• W2752035137 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7848463" @default.
• W2752035137 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28877783" @default.
• W2752035137 hasPublicationYear "2019" @default.
• W2752035137 type Work @default.
• W2752035137 sameAs 2752035137 @default.
• W2752035137 citedByCount "30" @default.
• W2752035137 countsByYear W27520351372018 @default.
• W2752035137 countsByYear W27520351372019 @default.
• W2752035137 countsByYear W27520351372020 @default.
• W2752035137 countsByYear W27520351372021 @default.
• W2752035137 countsByYear W27520351372022 @default.
• W2752035137 countsByYear W27520351372023 @default.
• W2752035137 crossrefType "journal-article" @default.
• W2752035137 hasAuthorship W2752035137A5003962764 @default.
• W2752035137 hasAuthorship W2752035137A5019502581 @default.
• W2752035137 hasAuthorship W2752035137A5028414570 @default.
• W2752035137 hasAuthorship W2752035137A5029584046 @default.
• W2752035137 hasAuthorship W2752035137A5080703203 @default.
• W2752035137 hasAuthorship W2752035137A5082019218 @default.
• W2752035137 hasAuthorship W2752035137A5084029581 @default.
• W2752035137 hasAuthorship W2752035137A5084190227 @default.
• W2752035137 hasBestOaLocation W27520351371 @default.
• W2752035137 hasConcept C121608353 @default.
• W2752035137 hasConcept C126322002 @default.
• W2752035137 hasConcept C134018914 @default.
• W2752035137 hasConcept C166471694 @default.
• W2752035137 hasConcept C2776256026 @default.
• W2752035137 hasConcept C2777164284 @default.
• W2752035137 hasConcept C2780482068 @default.
• W2752035137 hasConcept C502942594 @default.
• W2752035137 hasConcept C530470458 @default.
• W2752035137 hasConcept C55493867 @default.
• W2752035137 hasConcept C62112901 @default.
• W2752035137 hasConcept C71924100 @default.
• W2752035137 hasConcept C84606932 @default.
• W2752035137 hasConcept C86803240 @default.
• W2752035137 hasConceptScore W2752035137C121608353 @default.
• W2752035137 hasConceptScore W2752035137C126322002 @default.
• W2752035137 hasConceptScore W2752035137C134018914 @default.
• W2752035137 hasConceptScore W2752035137C166471694 @default.
• W2752035137 hasConceptScore W2752035137C2776256026 @default.
• W2752035137 hasConceptScore W2752035137C2777164284 @default.
• W2752035137 hasConceptScore W2752035137C2780482068 @default.
• W2752035137 hasConceptScore W2752035137C502942594 @default.
• W2752035137 hasConceptScore W2752035137C530470458 @default.
• W2752035137 hasConceptScore W2752035137C55493867 @default.
• W2752035137 hasConceptScore W2752035137C62112901 @default.
• W2752035137 hasConceptScore W2752035137C71924100 @default.

• next