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- W2752037145 endingPage "1291" @default.
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- W2752037145 abstract "The inhibition of mevalonate kinase (MVK) by downstream metabolites is an important mechanism in the regulation of isoprenoid production in a broad range of organisms. The first feedback-resistant MVK was previously discovered in the methanogenic archaeon Methanosarcinamazei. Here, we report the cloning, expression, purification, kinetic characterization and inhibition analysis of MVKs from two other methanogens, Methanosaetaconcilii and Methanocellapaludicola. Similar to the M. mazei MVK, these enzymes were not inhibited by diphosphomevalonate (DPM), dimethylallyl diphosphate (DMAPP), isopentenyldiphosphate (IPP), geranylpyrophosphate (GPP) or farnesylpyrophosphate (FPP). However, they exhibited significantly higher affinity to mevalonate and higher catalytic efficiency than the previously characterized enzyme." @default.
- W2752037145 created "2017-09-15" @default.
- W2752037145 creator A5004717473 @default.
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- W2752037145 date "2017-09-01" @default.
- W2752037145 modified "2023-10-10" @default.
- W2752037145 title "Characterization of feedback-resistant mevalonate kinases from the methanogenic archaeons Methanosaeta concilii and Methanocella paludicola" @default.
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- W2752037145 doi "https://doi.org/10.1099/mic.0.000510" @default.
- W2752037145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5817203" @default.
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