FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2752078504> ?p ?o ?g. }

• W2752078504 abstract "Current antiretroviral therapy (ART) used to treat human immunodeficiency virus (HIV) patients is life-long because it only suppresses de novo infections. Recent efforts to eliminate HIV have tested the ability of a number of agents to reactivate (‘Kick’) the well-known latent reservoir. This approach is rooted in the assumption that once these cells are reactivated the host’s immune system itself will eliminate (‘Kill’) the virus. While many agents have been shown to reactivate large quantities of the latent reservoir, the impact on the size of the latent reservoir has been negligible. This suggests that the immune system is not sufficient to eliminate reactivated reservoirs. Thus, there is a need for more emphasis on ‘kill’ strategies in HIV cure research, and how these might work in combination with current or future kick strategies. We conducted a landscape review of HIV ‘cure’ clinical trials using ‘kick and kill’ approaches. We identified and reviewed current available clinical trial results in human participants as well as ongoing and planned clinical trials. We dichotomized trials by whether they did not include or include a ‘kill’ agent. We extracted potential reasons why the ‘kill’ is missing from current ‘kick and kill’ strategies. We subsequently summarized and reviewed current ‘kill’ strategies have entered the phase of clinical trial testing in human participants and highlighted those with the greatest promise. The identified ‘kick’ trials only showed promise on surrogate measures activating latent T-cells, but did not show any positive effects on clinical ‘cure’ measures. Of the ‘kill’ agents currently being tested in clinical trials, early results have shown small but meaningful proportions of participants remaining off ART for several months with broadly neutralizing antibodies, as well as agents for regulating immune cell responses. A similar result was also recently observed in a trial combining a conventional ‘kick’ with a vaccine immune booster (‘kill’). While an understanding of the efficacy of each individual component is crucial, no single ‘kick’ or ‘kill’ agent is likely to be a fully effective cure. Rather, the solution is likely found in a combination of multiple ‘kick and kill’ interventions." @default.
• W2752078504 created "2017-09-15" @default.
• W2752078504 creator A5001585828 @default.
• W2752078504 creator A5003715359 @default.
• W2752078504 creator A5028521278 @default.
• W2752078504 creator A5050155313 @default.
• W2752078504 creator A5071826511 @default.
• W2752078504 date "2017-08-29" @default.
• W2752078504 modified "2023-10-18" @default.
• W2752078504 title "Landscape review of current HIV ‘kick and kill’ cure research - some kicking, not enough killing" @default.
• W2752078504 cites W1692094227 @default.
• W2752078504 cites W1768337933 @default.
• W2752078504 cites W1776874837 @default.
• W2752078504 cites W1866327060 @default.
• W2752078504 cites W1973694997 @default.
• W2752078504 cites W1975506525 @default.
• W2752078504 cites W1977282539 @default.
• W2752078504 cites W1978674283 @default.
• W2752078504 cites W1979058462 @default.
• W2752078504 cites W1982884889 @default.
• W2752078504 cites W1998093208 @default.
• W2752078504 cites W2004040286 @default.
• W2752078504 cites W2004319639 @default.
• W2752078504 cites W2006907788 @default.
• W2752078504 cites W2010165685 @default.
• W2752078504 cites W2011136801 @default.
• W2752078504 cites W2011208161 @default.
• W2752078504 cites W2013051750 @default.
• W2752078504 cites W2038110764 @default.
• W2752078504 cites W204100860 @default.
• W2752078504 cites W2051879794 @default.
• W2752078504 cites W2052756867 @default.
• W2752078504 cites W2055142955 @default.
• W2752078504 cites W2055796578 @default.
• W2752078504 cites W2080821453 @default.
• W2752078504 cites W2081064241 @default.
• W2752078504 cites W2082211638 @default.
• W2752078504 cites W2085384576 @default.
• W2752078504 cites W2090238266 @default.
• W2752078504 cites W2095570051 @default.
• W2752078504 cites W2101066888 @default.
• W2752078504 cites W2101516953 @default.
• W2752078504 cites W2113822425 @default.
• W2752078504 cites W2114538357 @default.
• W2752078504 cites W2119779320 @default.
• W2752078504 cites W2124058652 @default.
• W2752078504 cites W2125927970 @default.
• W2752078504 cites W2130651313 @default.
• W2752078504 cites W2135018398 @default.
• W2752078504 cites W2135547889 @default.
• W2752078504 cites W2135814503 @default.
• W2752078504 cites W2142014345 @default.
• W2752078504 cites W2143072084 @default.
• W2752078504 cites W2146666488 @default.
• W2752078504 cites W2150457116 @default.
• W2752078504 cites W2151980311 @default.
• W2752078504 cites W2157737444 @default.
• W2752078504 cites W2161028404 @default.
• W2752078504 cites W2166378435 @default.
• W2752078504 cites W2167867167 @default.
• W2752078504 cites W2173759909 @default.
• W2752078504 cites W2177904182 @default.
• W2752078504 cites W2185449687 @default.
• W2752078504 cites W2240032856 @default.
• W2752078504 cites W2272185077 @default.
• W2752078504 cites W2308542537 @default.
• W2752078504 cites W2324835369 @default.
• W2752078504 cites W2330954981 @default.
• W2752078504 cites W2332265082 @default.
• W2752078504 cites W2347047438 @default.
• W2752078504 cites W2394566891 @default.
• W2752078504 cites W2410813747 @default.
• W2752078504 cites W2417209002 @default.
• W2752078504 cites W2470126287 @default.
• W2752078504 cites W2473608950 @default.
• W2752078504 cites W2512183579 @default.
• W2752078504 cites W2531054429 @default.
• W2752078504 cites W2531363165 @default.
• W2752078504 cites W2556485149 @default.
• W2752078504 cites W2586226836 @default.
• W2752078504 cites W2593700719 @default.
• W2752078504 cites W2598871150 @default.
• W2752078504 cites W2605530771 @default.
• W2752078504 cites W2606314694 @default.
• W2752078504 cites W2781948754 @default.
• W2752078504 cites W2884222216 @default.
• W2752078504 cites W422705859 @default.
• W2752078504 cites W4230744147 @default.
• W2752078504 cites W4243136411 @default.
• W2752078504 doi "https://doi.org/10.1186/s12879-017-2683-3" @default.
• W2752078504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5576299" @default.
• W2752078504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28851294" @default.
• W2752078504 hasPublicationYear "2017" @default.
• W2752078504 type Work @default.
• W2752078504 sameAs 2752078504 @default.
• W2752078504 citedByCount "59" @default.
• W2752078504 countsByYear W27520785042018 @default.
• W2752078504 countsByYear W27520785042019 @default.
• W2752078504 countsByYear W27520785042020 @default.
• W2752078504 countsByYear W27520785042021 @default.

• next