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• W2752085764 endingPage "2574" @default.
• W2752085764 startingPage "2561" @default.
• W2752085764 abstract "Therapeutic cancer vaccines have gained significant popularity in recent years as new approaches for specific oncologic indications emerge. Three therapeutic cancer vaccines are FDA approved and one is currently approved by the EMA as monotherapy with modest treatment effects. Combining therapeutic cancer vaccines with other treatment modalities like radiotherapy (RT), hormone therapy, immunotherapy, and/or chemotherapy have been investigated as a means to enhance immune response and treatment efficacy. There is growing preclinical and clinical data that combination of checkpoint inhibitors and vaccines can induce immunogenic intensification with favorable outcomes. Additionally, novel methods for identifying targetable neoantigens hold promise for personalized vaccine development. In this article, we review the rationale for various therapeutic combinations, clinical trial experiences, and future directions. We also highlight the most promising developments that could lead to approval of novel therapeutic cancer vaccines." @default.
• W2752085764 created "2017-09-15" @default.
• W2752085764 creator A5000853357 @default.
• W2752085764 creator A5022515427 @default.
• W2752085764 creator A5046300035 @default.
• W2752085764 creator A5089085223 @default.
• W2752085764 date "2017-08-31" @default.
• W2752085764 modified "2023-10-10" @default.
• W2752085764 title "Cancer vaccines: Enhanced immunogenic modulation through therapeutic combinations" @default.
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