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- W2752123200 abstract "Chromosomal abnormalities have long been recognized as a cause of menstrual cycle disorders, premature ovarian insufficiency, and recurrent pregnancy loss. In women with X chromosome abnormalities, premature ovarian insufficiency is mainly a consequence of ovarian follicle depletion, due to insufficient initial follicle number and/or spontaneous accelerated follicle loss. The level of X chromosome mosaicism and its reproductive significance is still under debate. In our study, we evaluated the contribution of X chromosome abnormalities in women with sporadic idiopathic premature ovarian insufficiency (POI) and in women with a history of recurrent pregnancy loss. The results show that X aneuploidy and low-level mosaicism have reproductive significance in the phenotypically normal women with recurrent pregnancy loss and/or fertility problems. These results have practical implications for genetic counseling and fertility treatment." @default.
- W2752123200 created "2017-09-15" @default.
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- W2752123200 date "2017-08-30" @default.
- W2752123200 modified "2023-10-03" @default.
- W2752123200 title "Chromosomal Abnormalities and Menstrual Cycle Disorders" @default.
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- W2752123200 doi "https://doi.org/10.5772/67795" @default.
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