Matches in SemOpenAlex for { <https://semopenalex.org/work/W2752133365> ?p ?o ?g. }
- W2752133365 endingPage "56" @default.
- W2752133365 startingPage "49" @default.
- W2752133365 abstract "Mechanics plays a crucial role in the growth, development, and therapeutics of tumors. In this paper, a nonlinear poroelastic theory is established to describe the mechanical behaviors of solid tumors. The free-swollen state of a tumor is chosen as the reference state, which enables us to avoid pursuing a dry and stress-free state that is hard to achieve for living tissues. Our results reveal that the compression resistance of a tumor is primarily attributed to glycosaminoglycan (GAG) swelling, and the compactness of cell aggregates is found to affect tumor consolidation. Over-expressed GAGs and dense cell aggregates can stiffen the tumor, a remodeling mechanism that makes the tumor with higher elastic modulus than its surrounding host tissues. Glycosaminoglycan chains also influence the transient mechanical response of the tumor by modulating the tissue permeability. The theoretical results show good agreement with relevant experimental observations. This study may not only deepen our understanding of tumorigenesis but also provide cues for developing novel anticancer strategies." @default.
- W2752133365 created "2017-09-15" @default.
- W2752133365 creator A5011276141 @default.
- W2752133365 creator A5059209114 @default.
- W2752133365 creator A5060889415 @default.
- W2752133365 creator A5090140942 @default.
- W2752133365 date "2017-11-01" @default.
- W2752133365 modified "2023-10-15" @default.
- W2752133365 title "A nonlinear poroelastic theory of solid tumors with glycosaminoglycan swelling" @default.
- W2752133365 cites W1512153219 @default.
- W2752133365 cites W1966686938 @default.
- W2752133365 cites W1972135632 @default.
- W2752133365 cites W1976295346 @default.
- W2752133365 cites W1983530966 @default.
- W2752133365 cites W1989095124 @default.
- W2752133365 cites W1990212229 @default.
- W2752133365 cites W1995120265 @default.
- W2752133365 cites W1998266575 @default.
- W2752133365 cites W2000956094 @default.
- W2752133365 cites W2008669501 @default.
- W2752133365 cites W2011931614 @default.
- W2752133365 cites W2013496530 @default.
- W2752133365 cites W2014282546 @default.
- W2752133365 cites W2019802059 @default.
- W2752133365 cites W2020304979 @default.
- W2752133365 cites W2026786928 @default.
- W2752133365 cites W2030453627 @default.
- W2752133365 cites W2035228603 @default.
- W2752133365 cites W2043967411 @default.
- W2752133365 cites W2045295282 @default.
- W2752133365 cites W2047016831 @default.
- W2752133365 cites W2049208430 @default.
- W2752133365 cites W2053482418 @default.
- W2752133365 cites W2055072688 @default.
- W2752133365 cites W2055091294 @default.
- W2752133365 cites W2058317253 @default.
- W2752133365 cites W2062664804 @default.
- W2752133365 cites W2081596299 @default.
- W2752133365 cites W2083559598 @default.
- W2752133365 cites W2086244192 @default.
- W2752133365 cites W2099052265 @default.
- W2752133365 cites W2100303404 @default.
- W2752133365 cites W2100509399 @default.
- W2752133365 cites W2116167491 @default.
- W2752133365 cites W2133235008 @default.
- W2752133365 cites W2136367991 @default.
- W2752133365 cites W2154198501 @default.
- W2752133365 cites W2159255182 @default.
- W2752133365 cites W2166295771 @default.
- W2752133365 cites W2171157655 @default.
- W2752133365 cites W2222783195 @default.
- W2752133365 cites W2271764126 @default.
- W2752133365 cites W2376800108 @default.
- W2752133365 cites W2410353738 @default.
- W2752133365 cites W2557024863 @default.
- W2752133365 cites W2571012263 @default.
- W2752133365 cites W2593381699 @default.
- W2752133365 cites W2599374588 @default.
- W2752133365 cites W2605094557 @default.
- W2752133365 cites W2605219841 @default.
- W2752133365 cites W950543727 @default.
- W2752133365 doi "https://doi.org/10.1016/j.jtbi.2017.08.021" @default.
- W2752133365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28859927" @default.
- W2752133365 hasPublicationYear "2017" @default.
- W2752133365 type Work @default.
- W2752133365 sameAs 2752133365 @default.
- W2752133365 citedByCount "23" @default.
- W2752133365 countsByYear W27521333652018 @default.
- W2752133365 countsByYear W27521333652019 @default.
- W2752133365 countsByYear W27521333652020 @default.
- W2752133365 countsByYear W27521333652021 @default.
- W2752133365 countsByYear W27521333652022 @default.
- W2752133365 countsByYear W27521333652023 @default.
- W2752133365 crossrefType "journal-article" @default.
- W2752133365 hasAuthorship W2752133365A5011276141 @default.
- W2752133365 hasAuthorship W2752133365A5059209114 @default.
- W2752133365 hasAuthorship W2752133365A5060889415 @default.
- W2752133365 hasAuthorship W2752133365A5090140942 @default.
- W2752133365 hasConcept C105569014 @default.
- W2752133365 hasConcept C120882062 @default.
- W2752133365 hasConcept C12554922 @default.
- W2752133365 hasConcept C153074725 @default.
- W2752133365 hasConcept C159985019 @default.
- W2752133365 hasConcept C181965411 @default.
- W2752133365 hasConcept C185592680 @default.
- W2752133365 hasConcept C192562407 @default.
- W2752133365 hasConcept C2778540859 @default.
- W2752133365 hasConcept C41625074 @default.
- W2752133365 hasConcept C55493867 @default.
- W2752133365 hasConcept C6648577 @default.
- W2752133365 hasConcept C86803240 @default.
- W2752133365 hasConceptScore W2752133365C105569014 @default.
- W2752133365 hasConceptScore W2752133365C120882062 @default.
- W2752133365 hasConceptScore W2752133365C12554922 @default.
- W2752133365 hasConceptScore W2752133365C153074725 @default.
- W2752133365 hasConceptScore W2752133365C159985019 @default.
- W2752133365 hasConceptScore W2752133365C181965411 @default.
- W2752133365 hasConceptScore W2752133365C185592680 @default.