Matches in SemOpenAlex for { <https://semopenalex.org/work/W2752207861> ?p ?o ?g. }
- W2752207861 abstract "Abstract The biomolecular interaction of a potential prototype drug phenolphthalein (PN) with the transport protein bovine serum albumin (BSA) has been investigated at physiological pH employing various spectroscopic techniques along with computational study. The effect of β-cyclodextrin (β-CD) on PN-bound protein has also been investigated. The interesting phenomenon of all findings is the spontaneous exothermic binding of PN with serum albumin through static quenching mechanism. The thermodynamic parameters (ΔS°, ΔH° & ΔG°) have been justified by the detailed understanding of the binding affinity of PN with protein. The binding displacement measurements and Auto Dock-based docking simulation unravels the probable binding location of PN within the hydrophilic sub-domain IB close to Sudlow site I of BSA where Trp-134 is housed. Although β-CD induces a marginal structural loss of protein, it have played dominant roles to stripping of denaturant from PN-BSA assembles. This study has undertaken to unravel the effect of drug binding of protein so as to rationalize the applicability of the drug molecule as a therapeutic agent and drug delivery." @default.
- W2752207861 created "2017-09-15" @default.
- W2752207861 creator A5033950340 @default.
- W2752207861 creator A5053084431 @default.
- W2752207861 creator A5081729872 @default.
- W2752207861 date "2017-10-01" @default.
- W2752207861 modified "2023-09-24" @default.
- W2752207861 title "Unraveling the binding of phenolphthalein with serum protein and releasing by β-cyclodextrin" @default.
- W2752207861 cites W1940388777 @default.
- W2752207861 cites W1964210347 @default.
- W2752207861 cites W1965234339 @default.
- W2752207861 cites W1966499993 @default.
- W2752207861 cites W1973292723 @default.
- W2752207861 cites W1984889285 @default.
- W2752207861 cites W1985235829 @default.
- W2752207861 cites W1989270637 @default.
- W2752207861 cites W1998929873 @default.
- W2752207861 cites W2001345257 @default.
- W2752207861 cites W2001907362 @default.
- W2752207861 cites W2004688141 @default.
- W2752207861 cites W2006514821 @default.
- W2752207861 cites W2008373083 @default.
- W2752207861 cites W2010536064 @default.
- W2752207861 cites W2011764481 @default.
- W2752207861 cites W2016861604 @default.
- W2752207861 cites W2020555135 @default.
- W2752207861 cites W2031281559 @default.
- W2752207861 cites W2041892125 @default.
- W2752207861 cites W2042415555 @default.
- W2752207861 cites W2045426004 @default.
- W2752207861 cites W2056344871 @default.
- W2752207861 cites W2058256627 @default.
- W2752207861 cites W2061746882 @default.
- W2752207861 cites W2067235678 @default.
- W2752207861 cites W2068057987 @default.
- W2752207861 cites W2075705506 @default.
- W2752207861 cites W2104571730 @default.
- W2752207861 cites W2110095303 @default.
- W2752207861 cites W2113272836 @default.
- W2752207861 cites W2130479394 @default.
- W2752207861 cites W2151872241 @default.
- W2752207861 cites W2158534713 @default.
- W2752207861 cites W2165186407 @default.
- W2752207861 cites W2165456161 @default.
- W2752207861 cites W2313912827 @default.
- W2752207861 cites W2325150407 @default.
- W2752207861 cites W2325971273 @default.
- W2752207861 cites W2339158758 @default.
- W2752207861 cites W2344366801 @default.
- W2752207861 cites W2603565812 @default.
- W2752207861 cites W3142567293 @default.
- W2752207861 cites W338319698 @default.
- W2752207861 cites W4211146992 @default.
- W2752207861 cites W81090018 @default.
- W2752207861 cites W819114308 @default.
- W2752207861 doi "https://doi.org/10.1016/j.molliq.2017.09.027" @default.
- W2752207861 hasPublicationYear "2017" @default.
- W2752207861 type Work @default.
- W2752207861 sameAs 2752207861 @default.
- W2752207861 citedByCount "9" @default.
- W2752207861 countsByYear W27522078612018 @default.
- W2752207861 countsByYear W27522078612019 @default.
- W2752207861 countsByYear W27522078612020 @default.
- W2752207861 countsByYear W27522078612021 @default.
- W2752207861 countsByYear W27522078612022 @default.
- W2752207861 crossrefType "journal-article" @default.
- W2752207861 hasAuthorship W2752207861A5033950340 @default.
- W2752207861 hasAuthorship W2752207861A5053084431 @default.
- W2752207861 hasAuthorship W2752207861A5081729872 @default.
- W2752207861 hasConcept C107824862 @default.
- W2752207861 hasConcept C121332964 @default.
- W2752207861 hasConcept C121745418 @default.
- W2752207861 hasConcept C12554922 @default.
- W2752207861 hasConcept C159110408 @default.
- W2752207861 hasConcept C165616093 @default.
- W2752207861 hasConcept C178790620 @default.
- W2752207861 hasConcept C185592680 @default.
- W2752207861 hasConcept C2777460917 @default.
- W2752207861 hasConcept C2779433975 @default.
- W2752207861 hasConcept C41685203 @default.
- W2752207861 hasConcept C51639874 @default.
- W2752207861 hasConcept C55493867 @default.
- W2752207861 hasConcept C62520636 @default.
- W2752207861 hasConcept C71924100 @default.
- W2752207861 hasConcept C86803240 @default.
- W2752207861 hasConcept C86807702 @default.
- W2752207861 hasConcept C91881484 @default.
- W2752207861 hasConceptScore W2752207861C107824862 @default.
- W2752207861 hasConceptScore W2752207861C121332964 @default.
- W2752207861 hasConceptScore W2752207861C121745418 @default.
- W2752207861 hasConceptScore W2752207861C12554922 @default.
- W2752207861 hasConceptScore W2752207861C159110408 @default.
- W2752207861 hasConceptScore W2752207861C165616093 @default.
- W2752207861 hasConceptScore W2752207861C178790620 @default.
- W2752207861 hasConceptScore W2752207861C185592680 @default.
- W2752207861 hasConceptScore W2752207861C2777460917 @default.
- W2752207861 hasConceptScore W2752207861C2779433975 @default.
- W2752207861 hasConceptScore W2752207861C41685203 @default.
- W2752207861 hasConceptScore W2752207861C51639874 @default.
- W2752207861 hasConceptScore W2752207861C55493867 @default.