Matches in SemOpenAlex for { <https://semopenalex.org/work/W2752208045> ?p ?o ?g. }
- W2752208045 endingPage "10" @default.
- W2752208045 startingPage "1" @default.
- W2752208045 abstract "Autophagy is a lysosomal degradation pathway that acts as a cytoprotective mechanism causing treatment resistance in various cancer cells. Recent studies showed that hydroxychloroquine can inhibit the latter step of autophagy and therefore enhance the anti-glioma efficiency of ZD6474, a tyrosine kinase inhibitor. However, the nonselective distribution of ZD6474 in vivo and the low penetrating ability of hydroxychloroquine when crossing the blood-brain barrier restrict their clinical use in glioma therapy. Here we coencapsulated ZD6474 and hydroxychloroquine into R6dGR peptide-modified liposomes (R6dGR-Lip) which can specifically recognize both integrin αvβ3 and neuropilin-1 receptors that are highly expressed on the endothelial cells and glioma cells. R6dGR significantly enhanced the brain targeting and overcame the blood-brain barrier. Our results confirmed that loading hydroxychloroquine into R6dGR-Lip blocked autophagic flux more efficiently than free hydroxychloroquine in glioma cells and significantly sensitized glioma cells to ZD6474-induced cell death in vitro and in vivo. The coencapsulated R6dGR-modified liposomes (ZD6474/HCQ-R6dGR-Lip) prolonged the medium survival time of intracranial C6 glioma bearing mice by 1.2-fold compared with ZD6474-R6dGR-Lip, 1.5-fold compared with free ZD6474/HCQ, and 1.8-fold compared with free ZD6474, exhibiting a synergistic therapeutic effect. Therefore, ZD6474/HCQ-R6dGR-Lip is presented as a potential strategy which could be further used for efficient anti-glioma therapy." @default.
- W2752208045 created "2017-09-15" @default.
- W2752208045 creator A5001421484 @default.
- W2752208045 creator A5002083216 @default.
- W2752208045 creator A5015594980 @default.
- W2752208045 creator A5026174200 @default.
- W2752208045 creator A5032276597 @default.
- W2752208045 creator A5040377010 @default.
- W2752208045 creator A5045413265 @default.
- W2752208045 creator A5046354867 @default.
- W2752208045 creator A5053985637 @default.
- W2752208045 creator A5063383746 @default.
- W2752208045 creator A5065502386 @default.
- W2752208045 creator A5070324904 @default.
- W2752208045 date "2018-01-01" @default.
- W2752208045 modified "2023-10-17" @default.
- W2752208045 title "Enhanced glioma therapy by synergistic inhibition of autophagy and tyrosine kinase activity" @default.
- W2752208045 cites W1964517982 @default.
- W2752208045 cites W1971495943 @default.
- W2752208045 cites W1973544766 @default.
- W2752208045 cites W1976246361 @default.
- W2752208045 cites W1977253304 @default.
- W2752208045 cites W1978111504 @default.
- W2752208045 cites W1981931125 @default.
- W2752208045 cites W1989658253 @default.
- W2752208045 cites W1996827572 @default.
- W2752208045 cites W2006892443 @default.
- W2752208045 cites W2009218512 @default.
- W2752208045 cites W2016040396 @default.
- W2752208045 cites W2025266915 @default.
- W2752208045 cites W2047710431 @default.
- W2752208045 cites W2055510039 @default.
- W2752208045 cites W2067817921 @default.
- W2752208045 cites W2079351077 @default.
- W2752208045 cites W2087614255 @default.
- W2752208045 cites W2088719674 @default.
- W2752208045 cites W2089316300 @default.
- W2752208045 cites W2103596198 @default.
- W2752208045 cites W2108086395 @default.
- W2752208045 cites W2117505049 @default.
- W2752208045 cites W2125464483 @default.
- W2752208045 cites W2134807618 @default.
- W2752208045 cites W2139008103 @default.
- W2752208045 cites W2140912399 @default.
- W2752208045 cites W2151335185 @default.
- W2752208045 cites W2153382082 @default.
- W2752208045 cites W2160909461 @default.
- W2752208045 cites W2163499656 @default.
- W2752208045 cites W2169923369 @default.
- W2752208045 cites W2344833749 @default.
- W2752208045 cites W2397280502 @default.
- W2752208045 cites W2417464115 @default.
- W2752208045 cites W2562710683 @default.
- W2752208045 cites W2752326209 @default.
- W2752208045 cites W3189920043 @default.
- W2752208045 doi "https://doi.org/10.1016/j.ijpharm.2017.09.007" @default.
- W2752208045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28887220" @default.
- W2752208045 hasPublicationYear "2018" @default.
- W2752208045 type Work @default.
- W2752208045 sameAs 2752208045 @default.
- W2752208045 citedByCount "26" @default.
- W2752208045 countsByYear W27522080452018 @default.
- W2752208045 countsByYear W27522080452019 @default.
- W2752208045 countsByYear W27522080452020 @default.
- W2752208045 countsByYear W27522080452021 @default.
- W2752208045 countsByYear W27522080452022 @default.
- W2752208045 countsByYear W27522080452023 @default.
- W2752208045 crossrefType "journal-article" @default.
- W2752208045 hasAuthorship W2752208045A5001421484 @default.
- W2752208045 hasAuthorship W2752208045A5002083216 @default.
- W2752208045 hasAuthorship W2752208045A5015594980 @default.
- W2752208045 hasAuthorship W2752208045A5026174200 @default.
- W2752208045 hasAuthorship W2752208045A5032276597 @default.
- W2752208045 hasAuthorship W2752208045A5040377010 @default.
- W2752208045 hasAuthorship W2752208045A5045413265 @default.
- W2752208045 hasAuthorship W2752208045A5046354867 @default.
- W2752208045 hasAuthorship W2752208045A5053985637 @default.
- W2752208045 hasAuthorship W2752208045A5063383746 @default.
- W2752208045 hasAuthorship W2752208045A5065502386 @default.
- W2752208045 hasAuthorship W2752208045A5070324904 @default.
- W2752208045 hasConcept C121608353 @default.
- W2752208045 hasConcept C126322002 @default.
- W2752208045 hasConcept C142724271 @default.
- W2752208045 hasConcept C150903083 @default.
- W2752208045 hasConcept C170493617 @default.
- W2752208045 hasConcept C185592680 @default.
- W2752208045 hasConcept C190283241 @default.
- W2752208045 hasConcept C203522944 @default.
- W2752208045 hasConcept C207001950 @default.
- W2752208045 hasConcept C2778227246 @default.
- W2752208045 hasConcept C2778820342 @default.
- W2752208045 hasConcept C2779123688 @default.
- W2752208045 hasConcept C2779134260 @default.
- W2752208045 hasConcept C3008058167 @default.
- W2752208045 hasConcept C42362537 @default.
- W2752208045 hasConcept C502942594 @default.
- W2752208045 hasConcept C524204448 @default.
- W2752208045 hasConcept C55493867 @default.