Matches in SemOpenAlex for { <https://semopenalex.org/work/W2752273271> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2752273271 endingPage "213" @default.
- W2752273271 startingPage "207" @default.
- W2752273271 abstract "Chikungunya virus (CHIKV) infection leads to activation of innate immune response by triggering Toll-like receptor (TLR) pathways resulting in elevated cytokines and type-I interferon levels. Genetic variations of these genes may influence human CHIKV-susceptibility and disease progression. Present study aimed to identify role of TLR polymorphisms in CHIKV-susceptibility and their association with cytokines and clinical symptoms. This is the first study illustrating certain genotypes of TLR-7 and TLR-8 SNPs viz. CT(p = 0.002)]; rs3853839[GC(p < 0.001), CC(p = 0.039)] and rs3764879[GC(p < 0.001)] were considerably associated with CHIKV susceptibility. Increased risk of CHIKV infection among male patients with CC-genotype (rs179010) (p = 0.028) and female patients with GT-genotype (rs5741880) (p = 0.019) was observed. Significant higher IFN-α (P = 0.002) levels among chikungunya TNF-α (P = 0.034) patients was reported. Chikungunya patients with rs179010-CC genotype showed significantly high IFN-α level(p = 0.003). Thus, these TLR variants might act as potential prognostic biomarkers for predicting CHIKV susceptibility among uninfected individuals." @default.
- W2752273271 created "2017-09-15" @default.
- W2752273271 creator A5053970587 @default.
- W2752273271 creator A5067426397 @default.
- W2752273271 date "2017-11-01" @default.
- W2752273271 modified "2023-10-14" @default.
- W2752273271 title "Association of toll-like receptor polymorphisms with susceptibility to chikungunya virus infection" @default.
- W2752273271 cites W1888914942 @default.
- W2752273271 cites W1971457453 @default.
- W2752273271 cites W1981987485 @default.
- W2752273271 cites W1986186646 @default.
- W2752273271 cites W1988598819 @default.
- W2752273271 cites W2004476696 @default.
- W2752273271 cites W2010643338 @default.
- W2752273271 cites W2017714954 @default.
- W2752273271 cites W2028357619 @default.
- W2752273271 cites W2060917702 @default.
- W2752273271 cites W2075442260 @default.
- W2752273271 cites W2120801593 @default.
- W2752273271 cites W2144505818 @default.
- W2752273271 cites W2153006199 @default.
- W2752273271 cites W2157730228 @default.
- W2752273271 cites W2162530578 @default.
- W2752273271 cites W2166006345 @default.
- W2752273271 cites W2166592200 @default.
- W2752273271 cites W2416567081 @default.
- W2752273271 doi "https://doi.org/10.1016/j.virol.2017.08.009" @default.
- W2752273271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28888110" @default.
- W2752273271 hasPublicationYear "2017" @default.
- W2752273271 type Work @default.
- W2752273271 sameAs 2752273271 @default.
- W2752273271 citedByCount "49" @default.
- W2752273271 countsByYear W27522732712018 @default.
- W2752273271 countsByYear W27522732712019 @default.
- W2752273271 countsByYear W27522732712020 @default.
- W2752273271 countsByYear W27522732712021 @default.
- W2752273271 countsByYear W27522732712022 @default.
- W2752273271 countsByYear W27522732712023 @default.
- W2752273271 crossrefType "journal-article" @default.
- W2752273271 hasAuthorship W2752273271A5053970587 @default.
- W2752273271 hasAuthorship W2752273271A5067426397 @default.
- W2752273271 hasConcept C104317684 @default.
- W2752273271 hasConcept C135763542 @default.
- W2752273271 hasConcept C136449434 @default.
- W2752273271 hasConcept C153209595 @default.
- W2752273271 hasConcept C159047783 @default.
- W2752273271 hasConcept C203014093 @default.
- W2752273271 hasConcept C2522874641 @default.
- W2752273271 hasConcept C2776178377 @default.
- W2752273271 hasConcept C2776709828 @default.
- W2752273271 hasConcept C2781273456 @default.
- W2752273271 hasConcept C54355233 @default.
- W2752273271 hasConcept C67636389 @default.
- W2752273271 hasConcept C86803240 @default.
- W2752273271 hasConcept C8891405 @default.
- W2752273271 hasConceptScore W2752273271C104317684 @default.
- W2752273271 hasConceptScore W2752273271C135763542 @default.
- W2752273271 hasConceptScore W2752273271C136449434 @default.
- W2752273271 hasConceptScore W2752273271C153209595 @default.
- W2752273271 hasConceptScore W2752273271C159047783 @default.
- W2752273271 hasConceptScore W2752273271C203014093 @default.
- W2752273271 hasConceptScore W2752273271C2522874641 @default.
- W2752273271 hasConceptScore W2752273271C2776178377 @default.
- W2752273271 hasConceptScore W2752273271C2776709828 @default.
- W2752273271 hasConceptScore W2752273271C2781273456 @default.
- W2752273271 hasConceptScore W2752273271C54355233 @default.
- W2752273271 hasConceptScore W2752273271C67636389 @default.
- W2752273271 hasConceptScore W2752273271C86803240 @default.
- W2752273271 hasConceptScore W2752273271C8891405 @default.
- W2752273271 hasLocation W27522732711 @default.
- W2752273271 hasLocation W27522732712 @default.
- W2752273271 hasOpenAccess W2752273271 @default.
- W2752273271 hasPrimaryLocation W27522732711 @default.
- W2752273271 hasRelatedWork W2059921566 @default.
- W2752273271 hasRelatedWork W2325831581 @default.
- W2752273271 hasRelatedWork W2409522096 @default.
- W2752273271 hasRelatedWork W2410851192 @default.
- W2752273271 hasRelatedWork W2760853624 @default.
- W2752273271 hasRelatedWork W2781047784 @default.
- W2752273271 hasRelatedWork W2885712202 @default.
- W2752273271 hasRelatedWork W2990802404 @default.
- W2752273271 hasRelatedWork W3196526829 @default.
- W2752273271 hasRelatedWork W4281968585 @default.
- W2752273271 hasVolume "511" @default.
- W2752273271 isParatext "false" @default.
- W2752273271 isRetracted "false" @default.
- W2752273271 magId "2752273271" @default.
- W2752273271 workType "article" @default.