Matches in SemOpenAlex for { <https://semopenalex.org/work/W2752556614> ?p ?o ?g. }
- W2752556614 abstract "Individualized assessment of hepatocellular carcinoma (HCC) risk in chronic liver disease remains challenging. Serum biomarkers including cytokines may offer helpful adjuncts to standard parameters for risk prediction. Our aim was to identify markers associated with increased HCC incidence. This was a prospective cohort study of 282 patients with both viral or non-viral chronic liver disease. Baseline serum cytokines and other markers were measured in multiplex with a commercially-available Luminex-based system. Patients were followed until death or HCC diagnosis. We performed Lasso-based survival analysis to determine parameters associated with HCC development. Cytokine mean florescence intensity (MFI) was the primary predictor and HCC development the primary outcome. 25 patients developed HCC with total follow-up of 1,363 person-years. Parameters associated with increased HCC incidence were cirrhosis, hepatic decompensation, and soluble serum intercellular adhesion molecule 1 (sICAM-1) MFI. No other molecules increased predictive power for HCC incidence. On univariate analysis, the parameters associated with HCC incidence in patients with cirrhosis were age, antiviral treatment, and high sICAM-1 MFI; on multivariate analysis, sICAM-1 remained associated with HCC development (adjusted HR = 2.75). On unbiased screening of serum cytokines and other markers in a diverse cohort, baseline sICAM-1 MFI is associated with HCC incidence." @default.
- W2752556614 created "2017-09-15" @default.
- W2752556614 creator A5011688144 @default.
- W2752556614 creator A5014107752 @default.
- W2752556614 creator A5035377248 @default.
- W2752556614 creator A5035416695 @default.
- W2752556614 creator A5041915018 @default.
- W2752556614 creator A5051652168 @default.
- W2752556614 creator A5055763642 @default.
- W2752556614 creator A5056240498 @default.
- W2752556614 creator A5057476899 @default.
- W2752556614 creator A5064696546 @default.
- W2752556614 creator A5071889616 @default.
- W2752556614 creator A5080138550 @default.
- W2752556614 creator A5085931831 @default.
- W2752556614 date "2017-09-11" @default.
- W2752556614 modified "2023-09-26" @default.
- W2752556614 title "Soluble intercellular adhesion molecule-1 is associated with hepatocellular carcinoma risk: multiplex analysis of serum markers" @default.
- W2752556614 cites W1533394020 @default.
- W2752556614 cites W1562761383 @default.
- W2752556614 cites W1607998554 @default.
- W2752556614 cites W1763686333 @default.
- W2752556614 cites W1870126434 @default.
- W2752556614 cites W1963564133 @default.
- W2752556614 cites W1966357284 @default.
- W2752556614 cites W1983469579 @default.
- W2752556614 cites W1986242326 @default.
- W2752556614 cites W2000799034 @default.
- W2752556614 cites W2002483134 @default.
- W2752556614 cites W2009671859 @default.
- W2752556614 cites W2012824806 @default.
- W2752556614 cites W2014116209 @default.
- W2752556614 cites W2015420121 @default.
- W2752556614 cites W2022969414 @default.
- W2752556614 cites W2039845199 @default.
- W2752556614 cites W2047389074 @default.
- W2752556614 cites W2054132514 @default.
- W2752556614 cites W2056853546 @default.
- W2752556614 cites W2057814456 @default.
- W2752556614 cites W2060749612 @default.
- W2752556614 cites W2068524531 @default.
- W2752556614 cites W2077127518 @default.
- W2752556614 cites W2086127478 @default.
- W2752556614 cites W2095591310 @default.
- W2752556614 cites W2106644629 @default.
- W2752556614 cites W2113593386 @default.
- W2752556614 cites W2114718114 @default.
- W2752556614 cites W2115523370 @default.
- W2752556614 cites W2133298831 @default.
- W2752556614 cites W2136415416 @default.
- W2752556614 cites W2154643458 @default.
- W2752556614 cites W2163403599 @default.
- W2752556614 cites W2163486683 @default.
- W2752556614 cites W2165984116 @default.
- W2752556614 cites W2168076454 @default.
- W2752556614 cites W2343159740 @default.
- W2752556614 cites W2591717879 @default.
- W2752556614 cites W942602198 @default.
- W2752556614 doi "https://doi.org/10.1038/s41598-017-10498-5" @default.
- W2752556614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5593940" @default.
- W2752556614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28894136" @default.
- W2752556614 hasPublicationYear "2017" @default.
- W2752556614 type Work @default.
- W2752556614 sameAs 2752556614 @default.
- W2752556614 citedByCount "13" @default.
- W2752556614 countsByYear W27525566142018 @default.
- W2752556614 countsByYear W27525566142019 @default.
- W2752556614 countsByYear W27525566142021 @default.
- W2752556614 countsByYear W27525566142022 @default.
- W2752556614 crossrefType "journal-article" @default.
- W2752556614 hasAuthorship W2752556614A5011688144 @default.
- W2752556614 hasAuthorship W2752556614A5014107752 @default.
- W2752556614 hasAuthorship W2752556614A5035377248 @default.
- W2752556614 hasAuthorship W2752556614A5035416695 @default.
- W2752556614 hasAuthorship W2752556614A5041915018 @default.
- W2752556614 hasAuthorship W2752556614A5051652168 @default.
- W2752556614 hasAuthorship W2752556614A5055763642 @default.
- W2752556614 hasAuthorship W2752556614A5056240498 @default.
- W2752556614 hasAuthorship W2752556614A5057476899 @default.
- W2752556614 hasAuthorship W2752556614A5064696546 @default.
- W2752556614 hasAuthorship W2752556614A5071889616 @default.
- W2752556614 hasAuthorship W2752556614A5080138550 @default.
- W2752556614 hasAuthorship W2752556614A5085931831 @default.
- W2752556614 hasBestOaLocation W27525566141 @default.
- W2752556614 hasConcept C120665830 @default.
- W2752556614 hasConcept C121332964 @default.
- W2752556614 hasConcept C126322002 @default.
- W2752556614 hasConcept C143998085 @default.
- W2752556614 hasConcept C144301174 @default.
- W2752556614 hasConcept C188816634 @default.
- W2752556614 hasConcept C203014093 @default.
- W2752556614 hasConcept C2777214474 @default.
- W2752556614 hasConcept C2778019345 @default.
- W2752556614 hasConcept C38180746 @default.
- W2752556614 hasConcept C61511704 @default.
- W2752556614 hasConcept C71924100 @default.
- W2752556614 hasConcept C72563966 @default.
- W2752556614 hasConcept C90924648 @default.
- W2752556614 hasConceptScore W2752556614C120665830 @default.
- W2752556614 hasConceptScore W2752556614C121332964 @default.