Matches in SemOpenAlex for { <https://semopenalex.org/work/W2752561188> ?p ?o ?g. }
- W2752561188 endingPage "4979" @default.
- W2752561188 startingPage "4970" @default.
- W2752561188 abstract "Abstract The development of immunotherapy is an important breakthrough for the treatment of cancer, with antitumor efficacy observed in a wide variety of tumors. To optimize immunotherapy use, approaches must be developed to identify which patients are likely to achieve benefit. To minimize therapeutic toxicities and costs, understanding the ideal choice and sequencing of the numerous immuno-oncology agents available for individual patients is thus critical, but fraught with challenges. The immune tumor microenvironment (TME) is a unique aspect of the response to immuno-oncology agents and measurement of single biomarkers does not adequately capture these complex interactions. Therefore, multiple potential biomarkers are likely needed. Current candidates in this area include PD-L1 expression, CD8+ tumor-infiltrating lymphocytes, tumor mutation load and neoantigen burden, immune-related gene signatures, and multiplex IHC assays that examine the pharmacodynamic and spatial interactions of the TME. The most fruitful investigations are likely to use several techniques to predict response and interrogate mechanisms of resistance. Immuno-oncology biomarker research must employ validated assays to ask focused research questions utilizing clinically annotated tissue collections and biomarker-focused clinical trial designs to investigate specific endpoints. Real-time input from patients and their advocates into biomarker discovery is necessary to ensure that the investigations pursued will improve both clinical outcomes and quality of life. We herein provide a framework of recommendations to guide the search for immuno-oncology biomarkers of value. Clin Cancer Res; 23(17); 4970–9. ©2017 AACR. See all articles in this CCR Focus section, “Clinical Trial Design Considerations in the Immuno-oncology Era.”" @default.
- W2752561188 created "2017-09-15" @default.
- W2752561188 creator A5021514634 @default.
- W2752561188 creator A5028285949 @default.
- W2752561188 creator A5033078993 @default.
- W2752561188 creator A5053602981 @default.
- W2752561188 creator A5065634805 @default.
- W2752561188 creator A5079171882 @default.
- W2752561188 date "2017-08-31" @default.
- W2752561188 modified "2023-10-17" @default.
- W2752561188 title "The Challenge for Development of Valuable Immuno-oncology Biomarkers" @default.
- W2752561188 cites W1601679057 @default.
- W2752561188 cites W1940241680 @default.
- W2752561188 cites W1966107523 @default.
- W2752561188 cites W1967835984 @default.
- W2752561188 cites W1971061361 @default.
- W2752561188 cites W1982488143 @default.
- W2752561188 cites W2008389446 @default.
- W2752561188 cites W2032166347 @default.
- W2752561188 cites W2039123767 @default.
- W2752561188 cites W2042699075 @default.
- W2752561188 cites W2049553585 @default.
- W2752561188 cites W2064607202 @default.
- W2752561188 cites W2097995306 @default.
- W2752561188 cites W2101653483 @default.
- W2752561188 cites W2104347254 @default.
- W2752561188 cites W2104885590 @default.
- W2752561188 cites W2105477397 @default.
- W2752561188 cites W2107429737 @default.
- W2752561188 cites W2109485845 @default.
- W2752561188 cites W2119301589 @default.
- W2752561188 cites W2120002004 @default.
- W2752561188 cites W2120431466 @default.
- W2752561188 cites W2123543995 @default.
- W2752561188 cites W2124427232 @default.
- W2752561188 cites W2125071097 @default.
- W2752561188 cites W2125112000 @default.
- W2752561188 cites W2125616358 @default.
- W2752561188 cites W2136303546 @default.
- W2752561188 cites W2136731993 @default.
- W2752561188 cites W2138134458 @default.
- W2752561188 cites W2143488876 @default.
- W2752561188 cites W2147622445 @default.
- W2752561188 cites W2160834915 @default.
- W2752561188 cites W2166662937 @default.
- W2752561188 cites W2167645795 @default.
- W2752561188 cites W2171741398 @default.
- W2752561188 cites W2181134504 @default.
- W2752561188 cites W2185075416 @default.
- W2752561188 cites W2191164563 @default.
- W2752561188 cites W2275606382 @default.
- W2752561188 cites W2291298003 @default.
- W2752561188 cites W2297174255 @default.
- W2752561188 cites W2309483848 @default.
- W2752561188 cites W2337659275 @default.
- W2752561188 cites W2338576144 @default.
- W2752561188 cites W2339890238 @default.
- W2752561188 cites W2346108121 @default.
- W2752561188 cites W2383119765 @default.
- W2752561188 cites W2442299771 @default.
- W2752561188 cites W2465860350 @default.
- W2752561188 cites W2484958770 @default.
- W2752561188 cites W2488061344 @default.
- W2752561188 cites W2498858311 @default.
- W2752561188 cites W2500125655 @default.
- W2752561188 cites W2510824538 @default.
- W2752561188 cites W2526085171 @default.
- W2752561188 cites W2526607882 @default.
- W2752561188 cites W2527905628 @default.
- W2752561188 cites W2559382297 @default.
- W2752561188 cites W2560367415 @default.
- W2752561188 cites W2572174216 @default.
- W2752561188 cites W2582289619 @default.
- W2752561188 cites W2609973112 @default.
- W2752561188 cites W2612419201 @default.
- W2752561188 cites W2740073617 @default.
- W2752561188 cites W2751649617 @default.
- W2752561188 cites W2752475919 @default.
- W2752561188 cites W2753890414 @default.
- W2752561188 cites W2796950727 @default.
- W2752561188 cites W2889558875 @default.
- W2752561188 cites W2949158494 @default.
- W2752561188 doi "https://doi.org/10.1158/1078-0432.ccr-16-3063" @default.
- W2752561188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5657536" @default.
- W2752561188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28864725" @default.
- W2752561188 hasPublicationYear "2017" @default.
- W2752561188 type Work @default.
- W2752561188 sameAs 2752561188 @default.
- W2752561188 citedByCount "73" @default.
- W2752561188 countsByYear W27525611882017 @default.
- W2752561188 countsByYear W27525611882018 @default.
- W2752561188 countsByYear W27525611882019 @default.
- W2752561188 countsByYear W27525611882020 @default.
- W2752561188 countsByYear W27525611882021 @default.
- W2752561188 countsByYear W27525611882022 @default.
- W2752561188 countsByYear W27525611882023 @default.
- W2752561188 crossrefType "journal-article" @default.
- W2752561188 hasAuthorship W2752561188A5021514634 @default.