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- W2752580953 abstract "Oxidative stress has been proposed to play a key role in malignant hyperthermia (MH), a syndrome caused by excessive Ca 2+ release in skeletal muscle. Incidence of mortality in male calsequestrin-1 knockout (CASQ1-null) mice during exposure to halothane and heat (a syndrome closely resembling human MH) is far greater than that in females. To investigate the possible role of sex hormones in this still unexplained gender difference, we treated male and female CASQ1-null mice for 1 month, respectively, with Premarin (conjugated estrogens) and leuprolide (GnRH analog) and discovered that during exposure to halothane and heat Premarin reduced the mortality rate in males (79–27% and 86–20%), while leuprolide increased the incidence of mortality in females (18–73% and 24–82%). We then evaluated the (a) responsiveness of isolated muscles to temperature and caffeine, (b) sarcoplasmic reticulum (SR) Ca 2+ release in single fibers, and (c) oxidative stress and the expression levels of main enzymes involved in the regulation of the redox balance in muscle. Premarin treatment reduced the temperature and caffeine sensitivity of EDL muscles, normalized SR Ca 2+ release, and reduced oxidative stress in males, suggesting that female sex hormones may protect mice from lethal hyperthermic episodes by reducing both the SR Ca 2+ leak and oxidative stress." @default.
- W2752580953 created "2017-09-15" @default.
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- W2752580953 date "2017-01-01" @default.
- W2752580953 modified "2023-10-13" @default.
- W2752580953 title "Estrogens Protect Calsequestrin-1 Knockout Mice from Lethal Hyperthermic Episodes by Reducing Oxidative Stress in Muscle" @default.
- W2752580953 cites W1482266123 @default.
- W2752580953 cites W1517812484 @default.
- W2752580953 cites W1559841125 @default.
- W2752580953 cites W1576137866 @default.
- W2752580953 cites W1590925313 @default.
- W2752580953 cites W1599595176 @default.
- W2752580953 cites W1604764621 @default.
- W2752580953 cites W1740533879 @default.
- W2752580953 cites W1948159539 @default.
- W2752580953 cites W1957992664 @default.
- W2752580953 cites W1964166811 @default.
- W2752580953 cites W1981467972 @default.
- W2752580953 cites W1983681572 @default.
- W2752580953 cites W1985025225 @default.
- W2752580953 cites W1985353602 @default.
- W2752580953 cites W1987203427 @default.
- W2752580953 cites W1992900987 @default.
- W2752580953 cites W1998719424 @default.
- W2752580953 cites W2005435382 @default.
- W2752580953 cites W2005558862 @default.
- W2752580953 cites W2008885463 @default.
- W2752580953 cites W2010469212 @default.
- W2752580953 cites W2017415739 @default.
- W2752580953 cites W2017709939 @default.
- W2752580953 cites W2023750276 @default.
- W2752580953 cites W2030180518 @default.
- W2752580953 cites W2030907498 @default.
- W2752580953 cites W2035685439 @default.
- W2752580953 cites W2038013299 @default.
- W2752580953 cites W2039932112 @default.
- W2752580953 cites W2040603631 @default.
- W2752580953 cites W2042971458 @default.
- W2752580953 cites W2049162643 @default.
- W2752580953 cites W2049789854 @default.
- W2752580953 cites W2051646835 @default.
- W2752580953 cites W2054031974 @default.
- W2752580953 cites W2055130924 @default.
- W2752580953 cites W2058324461 @default.
- W2752580953 cites W2061809791 @default.
- W2752580953 cites W2062541458 @default.
- W2752580953 cites W2065212513 @default.
- W2752580953 cites W2067254948 @default.
- W2752580953 cites W2072531353 @default.
- W2752580953 cites W2073703119 @default.
- W2752580953 cites W2084015464 @default.
- W2752580953 cites W2084983662 @default.
- W2752580953 cites W2085128107 @default.
- W2752580953 cites W2085950478 @default.
- W2752580953 cites W2091685634 @default.
- W2752580953 cites W2095409224 @default.
- W2752580953 cites W2102066423 @default.
- W2752580953 cites W2103382851 @default.
- W2752580953 cites W2103737595 @default.
- W2752580953 cites W2105241536 @default.
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- W2752580953 cites W2120712042 @default.
- W2752580953 cites W2123384023 @default.
- W2752580953 cites W2126620184 @default.
- W2752580953 cites W2130978648 @default.
- W2752580953 cites W2132298206 @default.
- W2752580953 cites W2140004926 @default.
- W2752580953 cites W2140925358 @default.
- W2752580953 cites W2142240313 @default.
- W2752580953 cites W2144739553 @default.
- W2752580953 cites W2149800618 @default.
- W2752580953 cites W2153947452 @default.
- W2752580953 cites W2156182651 @default.
- W2752580953 cites W2163073874 @default.
- W2752580953 cites W2603460820 @default.
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- W2752580953 cites W4229653650 @default.
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- W2752580953 doi "https://doi.org/10.1155/2017/6936897" @default.
- W2752580953 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5610815" @default.
- W2752580953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29062464" @default.
- W2752580953 hasPublicationYear "2017" @default.
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