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- W2752742488 abstract "Objective To explore the effect of hepatitis B virus(HBV) on the expression of apolipoprotein A1 (ApoA1) and its regulatory mechanism.Methods RT-PCR and Western blot were used to measure the expression of ApoA1 in HepG2 and HepG2.2.15 cells,serum ApoA1 and high density lipoprotein cholesterol(HDL-C) levels in patients with HBV infection and in healthy individuals were measured by biochemical analyzer,statistical difference was analyzed by SPSS13.0,HepG2 cells was co-transfected with ApoA1 promoter containing the luciferase gene and HBV infectious clone pHBV1.3,luciferase activity was measured,expression of ApoA1 in HepG2 cells was measured by RT-PCR and Western blot after transfected with pHBV1.3.Results Expression of ApoA1 mRNA and protein was lower in HepG2.2.15 cells than in HepG2 cells,serum ApoA1 and HDL-C levels were much lower in HBV patients as compared to healthy individuals( P＜0.05 ),HBV represses ApoA1 gene promoter activity,ApoA1 mRNA and protein expression in HepG2 cells.Conclusion HBV can inhibit the expression of ApoA1 bothin vivo and in vitro.Key words: Hepatitis B virus; Apolipoprotein A1; High density lipoprotein cholesterol" @default.
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- W2752742488 date "2012-06-30" @default.
- W2752742488 modified "2023-10-12" @default.
- W2752742488 title "Exploration of the effect and regulatory mechanism of hepatitis B virus on the expression of apolipoprotein A1" @default.
- W2752742488 doi "https://doi.org/10.3760/cma.j.issn.0254-5101.2012.06.005" @default.
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