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- W2752743234 abstract "The purpose of the research described herein was to develop simple, precise and accurate isocratic stabilityindicating reversed phase HPLC assay method for determination of simultaneous determination of Amlodipinebesylate, Olmesartan medoxomil and Hydrochlorothiazide solid dosage forms. Isocratic RP-HPLC method wasdeveloped on Phenomenex Gemini C18 250´ 4.6mm, 5I¼m column using mobile phase as 0.02M ammonium acetatebuffer pH 4.5 - Acetonitrile (60:40, v/v) at a flow rate of 1.0 ml/min and the detection was carried out at 241 nmusing photo-diode array detector. The drug was subjected to oxidation, hydrolysis, photolysis and heat to applystress condition. The validation element investigated showed that the method has acceptable specificity, accuracy,linearity, solution stability, precision and robustness." @default.
- W2752743234 created "2017-09-15" @default.
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- W2752743234 date "2013-01-01" @default.
- W2752743234 modified "2023-09-24" @default.
- W2752743234 title "Development and validation of stability indicating HPLC assay method forsimultaneous determination of amlodipine besylate, olmesartan medoxomiland hydrochlorothiazide in tablet formulation" @default.
- W2752743234 hasPublicationYear "2013" @default.
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