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• W2752797455 abstract "Significance Since Down syndrome (DS) is caused by trisomy of chromosome 21, prenatal diagnosis of DS is now possible. Nonetheless, parents of a fetus diagnosed with DS have only two choices: terminate the pregnancy or prepare to raise a child with a serious disability. We developed a new compound, ALGERNON (altered generation of neurons), to provide a third option to these parents. Treatment of pregnant dams with ALGERNON prevented morphological brain abnormalities including a thinned cortical plate. Remarkably, these offspring exhibited normal cognitive behavior compared with untreated offspring with DS. ALGERNON has therapeutic potential for treating not only DS, but also numerous neurodevelopmental disorders." @default.
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• W2752797455 date "2017-09-05" @default.
• W2752797455 modified "2023-10-16" @default.
• W2752797455 title "Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice" @default.
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• W2752797455 doi "https://doi.org/10.1073/pnas.1704143114" @default.
• W2752797455 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5617268" @default.
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