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• W2752808978 abstract "In Brief Background Infection with Trypanosoma cruzi triggers inflammatory mechanisms and induces the activity of manganese-dependent superoxide dismutase. Genetic single-nucleotide polymorphisms of this enzyme generate proteins with reduced enzymatic activity. The aims of this study were to determine the frequency of the polymorphisms Ala-9Val and Ile58Thr of the manganese-dependent superoxide dismutase gene in DNA from chagasic and nonchagasic patients and to establish a relationship between these polymorphisms with chronic chagasic cardiomyopathy. Methods Two hundred fifty-eight unrelated patients underwent a general clinical examination and an electrocardiogram, a chest radiograph, and a 12-lead color Doppler echocardiogram were taken. Besides, we evaluate liver and renal function, lipid profile, and diagnosis of Chagas disease and genetic polymorphisms by polymerase chain reaction–restriction fragment length polymorphism. The patients were classified as nonchagasic group with negative serology for Chagas disease and the chagasic group with positive serology. This group was subdivided into asymptomatic when patients did not present abnormal cardiac symptoms and symptomatic if the chest radiograph, electrocardiogram, and/or color Doppler echocardiogram showed some alteration. Results The female chagasic population shows a high frequency of the ile58ile genotype (P = 0.010; odds ratio, 3.3; 95% confidence interval, 1.35–8.38). Lower frequency of the ala-9ala genotype was detected in symptomatic Chagas patients (P = 0.001; odds ratio, 3.147; 95% confidence interval, 1.39–7.482). The analysis revealed an interaction between the ala/ala + val/val genotype (P = 0.0108) with the plasma concentration of low-density lipoprotein cholesterol in the symptomatic Chagas group. Conclusions Our results show that the presence of the val allele is associated with chronic chagasic cardiomyopathy. The prognostic value of these results should be more deeply investigated. Chronic chagasic cardiomyopathy (CCC) caused by infection with Trypanosoma cruzi affects 30% of those infected. The oxidative function of the cardiac mitochondria is altered in CCC. The activity of the enzyme manganese superoxide dismutase (Mn-SOD) is important to maintain mitochondrial redox state. Several authors demonstrate that the val / val genetic variant of the Mn-SOD gene shows a decreased activity. The authors’ results associate chagasic patients with the val / val genotype with worse symptoms of CCC." @default.
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• W2752808978 date "2018-05-01" @default.
• W2752808978 modified "2023-09-27" @default.
• W2752808978 title "Genetic Polymorphisms of Manganese-Dependent Superoxide Dismutase in Chagas Disease" @default.
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• W2752808978 doi "https://doi.org/10.1097/ipc.0000000000000567" @default.
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