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- W2752809907 abstract "Abstract Platinum drugs continue to dominate medical oncology treatments but they have shortcomings associated with their use including dose-limiting toxic side effects and acquired or intrinsic drug resistance. Copper complexes have been extensively investigated as an alternative class of cancer therapeutic. In contrast to Pt drugs which covalently bind DNA nucleobases, Cu derivatives predominantly form non-covalent interactions with DNA – either via intercalation, electrostatic forces of attraction and/or major or minor groove binding. Sigman et al. pioneered research in the late 1970s into Cu complexes as potential chemical nuclease agents. Copper complexes have since been shown to induce DNA cleavage via nucleobase oxidation, hydrolysis of DNA phosphate esters and/or deoxyribose sugar oxidation. The scope of this review covers the period 2014 – present, with a distinct focus on Cu(II) systems which have been investigated as chemical nuclease agents. Specifically we describe how Cu complexes exert their chemical nuclease activity prior to presenting an overview of Cu complexes incorporating Schiff bases, amino acids, peptides, azoles, terpyridines or polypyridyls as ligands as well as including a section on dinuclear Cu complexes and Cu complexes incorporating natural products or bioactive ligands." @default.
- W2752809907 created "2017-09-15" @default.
- W2752809907 creator A5038709470 @default.
- W2752809907 creator A5049833090 @default.
- W2752809907 creator A5060921101 @default.
- W2752809907 date "2018-03-01" @default.
- W2752809907 modified "2023-10-15" @default.
- W2752809907 title "Copper complexes as artificial DNA metallonucleases: From Sigman’s reagent to next generation anti-cancer agent?" @default.
- W2752809907 cites W1603675492 @default.
- W2752809907 cites W1775731860 @default.
- W2752809907 cites W1783290419 @default.
- W2752809907 cites W183547841 @default.
- W2752809907 cites W1852168664 @default.
- W2752809907 cites W1950238178 @default.
- W2752809907 cites W1951164330 @default.
- W2752809907 cites W1952847716 @default.
- W2752809907 cites W1963747150 @default.
- W2752809907 cites W1965693173 @default.
- W2752809907 cites W1966521314 @default.
- W2752809907 cites W1970034671 @default.
- W2752809907 cites W1972231790 @default.
- W2752809907 cites W1973832810 @default.
- W2752809907 cites W1980578368 @default.
- W2752809907 cites W1983198174 @default.
- W2752809907 cites W1983790387 @default.
- W2752809907 cites W1984883623 @default.
- W2752809907 cites W1985869328 @default.
- W2752809907 cites W1986352746 @default.
- W2752809907 cites W1997854913 @default.
- W2752809907 cites W1998768729 @default.
- W2752809907 cites W2002199178 @default.
- W2752809907 cites W2005036369 @default.
- W2752809907 cites W2005078443 @default.
- W2752809907 cites W2005276174 @default.
- W2752809907 cites W2005723165 @default.
- W2752809907 cites W2006277851 @default.
- W2752809907 cites W2007567412 @default.
- W2752809907 cites W2011158618 @default.
- W2752809907 cites W2012108057 @default.
- W2752809907 cites W2012399634 @default.
- W2752809907 cites W2013869567 @default.
- W2752809907 cites W2014474658 @default.
- W2752809907 cites W2019508582 @default.
- W2752809907 cites W2021565138 @default.
- W2752809907 cites W2023137748 @default.
- W2752809907 cites W2023709279 @default.
- W2752809907 cites W2024637104 @default.
- W2752809907 cites W2026594509 @default.
- W2752809907 cites W2028161749 @default.
- W2752809907 cites W2039150265 @default.
- W2752809907 cites W2040527477 @default.
- W2752809907 cites W2040560507 @default.
- W2752809907 cites W2041499605 @default.
- W2752809907 cites W2042090512 @default.
- W2752809907 cites W2043646480 @default.
- W2752809907 cites W2052544200 @default.
- W2752809907 cites W2061431758 @default.
- W2752809907 cites W2070212138 @default.
- W2752809907 cites W2075171554 @default.
- W2752809907 cites W2075211172 @default.
- W2752809907 cites W2079067339 @default.
- W2752809907 cites W2080493328 @default.
- W2752809907 cites W2080598517 @default.
- W2752809907 cites W2084338840 @default.
- W2752809907 cites W2085380017 @default.
- W2752809907 cites W2089238592 @default.
- W2752809907 cites W2091348077 @default.
- W2752809907 cites W2092555653 @default.
- W2752809907 cites W2102949695 @default.
- W2752809907 cites W2103088199 @default.
- W2752809907 cites W2125521001 @default.
- W2752809907 cites W2132365804 @default.
- W2752809907 cites W2133634779 @default.
- W2752809907 cites W2135357230 @default.
- W2752809907 cites W2145374398 @default.
- W2752809907 cites W2145549507 @default.
- W2752809907 cites W2146301628 @default.
- W2752809907 cites W2155608255 @default.
- W2752809907 cites W2156919809 @default.
- W2752809907 cites W2158398633 @default.
- W2752809907 cites W2158787437 @default.
- W2752809907 cites W2158855398 @default.
- W2752809907 cites W2162695449 @default.
- W2752809907 cites W2172814983 @default.
- W2752809907 cites W2181136653 @default.
- W2752809907 cites W2198485298 @default.
- W2752809907 cites W2201511438 @default.
- W2752809907 cites W2204689679 @default.
- W2752809907 cites W2238803562 @default.
- W2752809907 cites W2263754971 @default.
- W2752809907 cites W2280796240 @default.
- W2752809907 cites W2282989227 @default.
- W2752809907 cites W2286254355 @default.
- W2752809907 cites W2295739520 @default.
- W2752809907 cites W2319386786 @default.
- W2752809907 cites W2321078795 @default.
- W2752809907 cites W2326938808 @default.
- W2752809907 cites W2336403468 @default.