Matches in SemOpenAlex for { <https://semopenalex.org/work/W2752893197> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2752893197 endingPage "204" @default.
- W2752893197 startingPage "195" @default.
- W2752893197 abstract "Comprehensive on-line two-dimensional liquid chromatography (LCxLC) is expected to generate impressive peak capacities, which makes it a method of choice for the analysis of complex samples such as pharmaceuticals. A comparative study of different sets of chromatographic conditions including stationary phase, pH additive and organic modifier was carried out with two real pharmaceutical samples in order to find out the best analytical conditions for implementation of one or several generic on-line LCxLC separations. Our choice was based on the evaluation of both degree of orthogonality and practical sample peak capacity under linear gradient conditions. The potential of 190 combinations of chromatographic systems was compared. A set of 3 RPLCxRPLC configurations was found to be very attractive for both samples and in good agreement with the findings of a previous study carried out with 17 model compounds, thereby supporting the idea of using generic LCxLC conditions in the pharmaceutical area. The three selected 2D-systems were implemented for the on-line RPLCxRPLC-UV/MS analysis of two pharmaceutical samples. It was shown, for each sample, that these 2D-systems were able to generate an effective peak capacity close to 1000 in less than 50 min. For each sample, baseline separation was obtained for every known compound and furthermore a large number of unknown impurities could also be separated and identified. Finally, in the proposed conditions, the total number of compounds detected was significantly improved from one RPLC separation to one RPLCxRPLC separation. Only a small additional gain was observed by performing a second RPLCxRPLC separation or even a third one." @default.
- W2752893197 created "2017-09-15" @default.
- W2752893197 creator A5001246131 @default.
- W2752893197 creator A5042142337 @default.
- W2752893197 creator A5057888090 @default.
- W2752893197 creator A5061496007 @default.
- W2752893197 creator A5071156412 @default.
- W2752893197 date "2018-02-01" @default.
- W2752893197 modified "2023-10-07" @default.
- W2752893197 title "Comprehensive two dimensional liquid chromatography as analytical strategy for pharmaceutical analysis" @default.
- W2752893197 cites W1138591158 @default.
- W2752893197 cites W1710558854 @default.
- W2752893197 cites W1967911426 @default.
- W2752893197 cites W1971003075 @default.
- W2752893197 cites W1980103804 @default.
- W2752893197 cites W1985880876 @default.
- W2752893197 cites W1996029368 @default.
- W2752893197 cites W2009630723 @default.
- W2752893197 cites W2021428150 @default.
- W2752893197 cites W2022595374 @default.
- W2752893197 cites W2025079709 @default.
- W2752893197 cites W2031813965 @default.
- W2752893197 cites W2034356373 @default.
- W2752893197 cites W2039698515 @default.
- W2752893197 cites W2051259474 @default.
- W2752893197 cites W2055063923 @default.
- W2752893197 cites W2069089889 @default.
- W2752893197 cites W2070636937 @default.
- W2752893197 cites W2075399587 @default.
- W2752893197 cites W2082996306 @default.
- W2752893197 cites W2317343890 @default.
- W2752893197 cites W2319029959 @default.
- W2752893197 cites W2334383591 @default.
- W2752893197 cites W2581320133 @default.
- W2752893197 cites W59432175 @default.
- W2752893197 doi "https://doi.org/10.1016/j.chroma.2017.08.070" @default.
- W2752893197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28899555" @default.
- W2752893197 hasPublicationYear "2018" @default.
- W2752893197 type Work @default.
- W2752893197 sameAs 2752893197 @default.
- W2752893197 citedByCount "25" @default.
- W2752893197 countsByYear W27528931972018 @default.
- W2752893197 countsByYear W27528931972019 @default.
- W2752893197 countsByYear W27528931972020 @default.
- W2752893197 countsByYear W27528931972021 @default.
- W2752893197 countsByYear W27528931972022 @default.
- W2752893197 countsByYear W27528931972023 @default.
- W2752893197 crossrefType "journal-article" @default.
- W2752893197 hasAuthorship W2752893197A5001246131 @default.
- W2752893197 hasAuthorship W2752893197A5042142337 @default.
- W2752893197 hasAuthorship W2752893197A5057888090 @default.
- W2752893197 hasAuthorship W2752893197A5061496007 @default.
- W2752893197 hasAuthorship W2752893197A5071156412 @default.
- W2752893197 hasConcept C113196181 @default.
- W2752893197 hasConcept C137777109 @default.
- W2752893197 hasConcept C17137986 @default.
- W2752893197 hasConcept C178790620 @default.
- W2752893197 hasConcept C179998833 @default.
- W2752893197 hasConcept C185592680 @default.
- W2752893197 hasConcept C198531522 @default.
- W2752893197 hasConcept C2524010 @default.
- W2752893197 hasConcept C33923547 @default.
- W2752893197 hasConcept C43617362 @default.
- W2752893197 hasConcept C71987851 @default.
- W2752893197 hasConceptScore W2752893197C113196181 @default.
- W2752893197 hasConceptScore W2752893197C137777109 @default.
- W2752893197 hasConceptScore W2752893197C17137986 @default.
- W2752893197 hasConceptScore W2752893197C178790620 @default.
- W2752893197 hasConceptScore W2752893197C179998833 @default.
- W2752893197 hasConceptScore W2752893197C185592680 @default.
- W2752893197 hasConceptScore W2752893197C198531522 @default.
- W2752893197 hasConceptScore W2752893197C2524010 @default.
- W2752893197 hasConceptScore W2752893197C33923547 @default.
- W2752893197 hasConceptScore W2752893197C43617362 @default.
- W2752893197 hasConceptScore W2752893197C71987851 @default.
- W2752893197 hasLocation W27528931971 @default.
- W2752893197 hasLocation W27528931972 @default.
- W2752893197 hasLocation W27528931973 @default.
- W2752893197 hasOpenAccess W2752893197 @default.
- W2752893197 hasPrimaryLocation W27528931971 @default.
- W2752893197 hasRelatedWork W1587967017 @default.
- W2752893197 hasRelatedWork W1985850906 @default.
- W2752893197 hasRelatedWork W1986344953 @default.
- W2752893197 hasRelatedWork W2059318893 @default.
- W2752893197 hasRelatedWork W2093107063 @default.
- W2752893197 hasRelatedWork W2094175395 @default.
- W2752893197 hasRelatedWork W3176637561 @default.
- W2752893197 hasRelatedWork W4232542516 @default.
- W2752893197 hasRelatedWork W834942123 @default.
- W2752893197 hasRelatedWork W3149967114 @default.
- W2752893197 hasVolume "1536" @default.
- W2752893197 isParatext "false" @default.
- W2752893197 isRetracted "false" @default.
- W2752893197 magId "2752893197" @default.
- W2752893197 workType "article" @default.