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- W2752930078 abstract "Polymeric nanoparticles have been extensively studied as drug delivery vehicles both in vitro and in vivo for the last two decades. In vitro methods to assess drug release profiles usually utilize degradation of nanoparticles in aqueous medium, followed by the measurement of the concentration of the released drug. This method, however, is difficult to use for drugs that are poorly water soluble. In this study, a protocol for measuring drug release kinetic using albumin solution as the medium is described. Albumin is a major blood transport protein, which mediates transport of many lipid soluble compounds including fatty acids, hormones, and bilirubin. The use of a dialysis-based system utilizing albumin dialysate solution allows hydrophobic drug release from a diverse set of drug delivery modalities is demonstrated. The method using liposomes and PLGA nanoparticles as drug carriers, and two model hydrophobic drugs, 17β-estradiol, and dexamethasone is validated." @default.
- W2752930078 created "2017-09-15" @default.
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- W2752930078 date "2017-09-25" @default.
- W2752930078 modified "2023-10-13" @default.
- W2752930078 title "Albumin-Assisted Method Allows Assessment of Release of Hydrophobic Drugs From Nanocarriers" @default.
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- W2752930078 doi "https://doi.org/10.1002/biot.201700337" @default.
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